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. 2024 Mar 6;13(4):187–199. doi: 10.1089/wound.2023.0097

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© Paulina Słonimska et al., 2024; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Effects of chemotherapeutic on peripheral nerves. CIPN inducing anticancer drugs attack microtubules, mitochondria, and DNA. Axonal damage in CIPN occurs through Wallerian degeneration, associated with microtubule stabilization and apoptosis, which involves mitochondrial destruction and DNA damage. These injuries lead to complications in the nervous system, such as capillary damage, neuritis, peripheral nerve damage, and demyelination, including dissociation of Schwann cells. (The drawing was created with BioRender.com). CIPN, chemotherapy-induced peripheral neuropathy.