Skip to main content
. Author manuscript; available in PMC: 2024 Apr 15.
Published in final edited form as: Biol Psychiatry. 2023 Sep 9;95(8):745–761. doi: 10.1016/j.biopsych.2023.08.023

Table 4.

Significant GREX-Phecode Associations

Gene Phecode Description Tissue Full Analysis Correcting for Pain Scores
z Score p FDR p Raw z Score p FDR p Raw
DCAKD Cardiac dysrhythmias Caudate, basal ganglia −4.98 .0084 6.18 × 10−7 −5.52 .0046 3.47 × 10−8
ECM1 Dysmetabolic syndrome X Cerebellar hemisphere 4.58 .0063 6.39 × 10−7
Cerebellum −4.99 .0228 4.61 ×10−6
Nucleus accumbens, basal ganglia 5.33 .026 7.89 ×10−6
ERICH2 Disc disorders/dorsopathies Amygdala 4.7 .0312 8.4 × 10−6 −4.42 .033 9.83 × 10−6
ILRUN (C6orf106) Primary thrombocytopenia Amygdala −4.47 .0176 1.98 ×10−6
Hypothalamus 4.81 .0176 2.59 × 10−6
Nucleus accumbens, basal ganglia 4.46 .024 5.3 × 10−6
Cortex −4.45 .0415 1.22 × 10−5
MON1B Anemias Spinal cord cervical C1 −4.58 .014 1.14 × 10−6
Amygdala 4.21 .0293 4.74 × 10−6
PACSIN3 Bullous dermatoses Nucleus accumbens, basal ganglia 4.87 .0076 1.54 × 10−6
RAD51 Disturbances of sulfur-bearing amino acid metabolism Substantia nigra 4.76 .0307 1.24 ×10−5
SCAI Inflammatory and toxic neuropathy Cortex 4.55 .0412 8.34 × 10−6
SLC38A3 Joint/ligament sprain Caudate, basal ganglia 4.37 .0002 9.62 × 10−8 6.00 4.34 × 10−06 1.92 × 10−9
Neurological disorders Caudate, basal ganglia 4.37 .0309 2.5 × 10−5
ZNF197 Hand/finger injuries and lacerations Substantia nigra 4.45 .048 8.45 × 10−6
ENSG00000278730 (Novel Transcript, lncRNA, a.k.a. RP11–147L13.11) Spondylosis with myelopathy Anterior cingulate cortex, BA 24 4.93 .0046 8.21 × 10−7
Cerebellum 4.59 .017 4.41 × 10−6
Cortex 5.05 .0046 4.46 × 10−7
Hypothalamus 4.37 .035 1.25 × 10−5

FDR correction carried out within gene; z score presents PheWAS z score value; tissue represents GREX tissue; pFDR presents GREX-phecode phenome-wide association study p value (FDR corrected); and pRaw presents uncorrected p value.

a.k.a., also known as; FDR, false discovery rate; GREX, genetically regulated gene expression; lncRNA, long noncoding RNA.