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. 2024 Feb 28;20:101746. doi: 10.1016/j.bonr.2024.101746

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© 2024 Published by Elsevier Inc.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Bone microarchitecture parameters in FLNB^WT/WT mice, FLNB^WT/G1586R mice and FLNB^{G1586R/G1586R} mice (3 male mice in each group, 8-week). Tb.vBMD was significantly lower in FLNB^{G1586R/G1586R} mice compared to FLNB^WT/WT mice. Tb.Th in the FLNB^{G1586R/G1586R} mice had a trend of downregulation, and Tb.Sp in the FLNB^{G1586R/G1586R} mice had a trend of upregulation, compared to FLNB^WT/WT mice, though not statistically significant. Abbreviations: Trabecular volumetric bone mineral density (Tb.vBMD), cortical volumetric bone mineral density (Ct.vBMD), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), bone volume fraction (BV/TV), trabecular number (Tb.N), bone surface/volume (BS/BV), and cortical bone thickness (Ct.Th).