Table 2.
The total number of gut microbiome and metabolites associated with psychoneurological symptoms
| Study group | Microbiome | Metabolites |
|---|---|---|
| Children with cancer at T0 (n = 21) | (n = 37) | (n = 388) |
| Cluster 1 (no symptoms) | 5 | 121 |
| Cluster 2 (no symptoms) | 8 | 121 |
| Cluster 3 (no symptoms) | 12 | 55 |
| Cluster 4 (no symptoms) | 4 | 12 |
| Cluster 5 (pain, anxiety, cognitive function) | 2 | 71 |
| Cluster 6 (fatigue, depressive symptoms) | 6 | 8 |
| Children with cancer at T1 (n = 12) | (n = 24) | (n = 375) |
| Cluster 1 (no symptoms) | 4 | 71 |
| Cluster 2 (no symptoms) | 12 | 92 |
| Cluster 3 (no symptoms) | 7 | 29 |
| Cluster 4 (fatigue, anxiety, depressive symptoms) | 1 | 48 |
| Cluster 5 (cognitive function) | 0 | 135 |
| Healthy controls (n = 14) | (n = 40) | (n = 492) |
| Cluster 1 (no symptoms) | 4 | 175 |
| Cluster 2 (no symptoms) | 10 | 75 |
| Cluster 3 (no symptoms) | 12 | 54 |
| Cluster 4 (no symptoms) | 7 | 22 |
| Cluster 5 (fatigue, cognitive function) | 5 | 111 |
| Cluster 6 (anxiety, depressive symptoms) | 2 | 55 |