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. 2024 Mar 9;12:49. doi: 10.1186/s40168-024-01774-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Networks of taxa and selected metabolites for verum complaints and verum tolerated at time point 2. The metabolites have been chosen in accordance with Fig. 5. A In Vc (complaints), ammonium and carbon dioxide are highlighted in violet, and O-glycans are highlighted in rose. B In Vt (tolerated), the predicted bile acids are highlighted in orange. In both networks, node size (metabolites and taxa) was scaled according to abundance; bacteria are highlighted in light grey and archaea (methanogens) in dark grey; edges were weighted according to their modeled flux, imported metabolites are connected by green lines, and exported metabolites are connected by pink lines. Network layout is based on an edge-weighted spring-embedded algorithm based on metabolic flux