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. 2024 Mar 8;21:66. doi: 10.1186/s12974-024-03052-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Proteomic analysis reveals reduction of astrogliosis in Q175 mice lacking Tyrobp. A Supervised Clustering using Partial Least Squares-Discriminant Analysis (PLS-DA). B Summary of the number of differentially expressed proteins (FDR < 0.05 and absolute log₂(fold change) > 0.2). Blue and red bars indicate downregulated and upregulated DEGs, respectively. C GO terms (biological process) associated with downregulated proteins from Q175 vs WT data sets after ConsensusPathDB overrepresentation analysis. D Top differentially expressed proteins in the striatum of Q175;Tyrobp^(−/−) vs. Q175 mice. E, F Plot showing Q175 vs WT (left) and Q175;Tyrobp^(−/−) vs Q175 (right) log₂ fold-change (LFC) in the transcriptome and proteome. The plot only includes those genes detected as both transcripts and proteins and also differentially expressed (adj. p-value < 0.1 for Q175 vs WT comparison; and nominal p-value < 0.05 for Q175;Tyrobp^(−/−) vs Q175 comparison). Gray color denotes that the gene was differentially expressed in the transcriptome and proteome with an adj. p-value < 0.1