Table 2.
GRADE1 Evidence Profile for studies on the association of NLR with BMD in post-menopausal women
| Certainty assessment | № of patients | Certainty7 | Importance | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias2 | Inconsistency3 | Indirectness4 | Imprecision5 | Publication bias6 | Participants, n | Cases, n | ||
| Osteoporosis | ||||||||||
| 7 | observational studies | not serious | very serious | not serious | not serious | none | 1499 | 871 |
⨁◯◯◯ Very low |
CRITICAL |
| Osteopenia | ||||||||||
| 7 | observational studies | not serious | very serious | not serious | not serious | none | 1358 | 810 |
⨁◯◯◯ Very low |
CRITICAL |
1Grading of Recommendations Assessment, Development and Evaluation
2Risk of bias based on Newcastle-Ottawa Scale
3When I2 was < 30% inconsistency considered as Not serious limitation, > 50 considered as serious and more than 75% considered as very serious limitation
5Serious limitations when there was fewer than 4000 participants for each outcome and very serious limitations when there was fewer than 300 participants for each outcome
6Funnel plot revealed no asymmetry; neither test of publication bias approached P < 0.10
7Data from cohort studies begin with a grade of “LOW”. Downgraded for very serious inconsistency