Table 3.
Sedation-related adverse events
| Events | Fentanyl (n = 79) | Esketamine (n = 81) | p |
|---|---|---|---|
| Oxygen desaturation | 20 (25.3) | 12 (14.8) | 0.097 |
| Severe oxygen desaturation | 1 (1.3) | 0 (0) | 0.494 |
| Hypotension | 52 (65.8) | 27 (33.3) | 0.001 |
| Hypertension | 0 (0) | 0 (0) | |
| Bradycardia | 11 (13.9) | 0 (0) | 0.001 |
| Tachycardia | 1 (1.3) | 0 (0) | 0.494 |
| Need for ephedrine | 26 (32.9) | 9 (11.1) | 0.001 |
| Need for phenylephrine | 28 (35.4) | 19 (23.5) | 0.096 |
| PONV | 0 (0) | 1 (1.2) | 0.506 |
| Pain | 1 (1.3) | 2 (2.5) | 0.497 |
| Bad mood state | 1 (1.3) | 1 (1.2) | 0.745 |
Abbreviations: PONV, postoperative nausea and vomiting
Data are presented as mean ± SD, n (%), or median (IQRs), with the P-value representing the significance level for differences between groups A and E (Student’s t-test, Mann–Whitney U test, Pearson’s χ2 test, or Fisher exact test)