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Increased hepatocyte injury, apoptosis and inflammation in HBV; Pten−/− livers. A Serum ALT and AST of WT, HBV, Pten−/−, and HBV; Pten−/− mice. B Cleaved-caspase 3 staining of 4-month-old WT, HBV, Pten−/−, and HBV; Pten−/− livers. C and D Immunoblotting analysis of 4-month-old WT, HBV, Pten−/−, and HBV; Pten.−/− livers. E IL6 mRNA level was determined by qRT-PCR (n = 7–10). Scale bar, 100 μm. Data were shown as mean ± SD, **p < 0.01, ***p < 0.001
