Table 2.
LD50 and TTD for mice challenged intranasally with type A or type B biofilm-forming variants
|
244 BF-1 |
255 BF-1 |
255 BF-4 |
||
|
LD50 (c.f.u.) |
317 |
> 460 000 |
2152 |
|
|
Median TTD (Days) |
1–10 |
>14 |
>14 |
>14 |
|
10–100 |
>14 |
>14 |
>14 |
|
|
100–1000 |
>14 |
>14 |
>14 |
|
|
1000–10 000 |
8 |
>14 |
11 |
|
|
10,000–100,000 |
7 |
>14 |
9 |
|
|
>100 000 |
7 |
>14 |
8 |
|
|
Pair-Wise Comparisons (Wald-test)* |
vs. FRAN244 |
P=0.0036 |
||
|
vs. FRAN255 |
P<0.0001 |
P<0.0001 |
*Challenge dose for the parental strains was 105 c.f.u. (FRAN244) and 8 c.f.u. (FRAN255).
P values for comparisons among strains were determined by Wald Chi-square tests based on a Cox regression model.
ns, not significant (P>0.05); TTD, time to death.