Fig. 3.

Sex differences in the systemic T cell response following stroke. Tian et al. [188] profiled gene expression in the blood from male and female ischemic stroke patients (≤ 3, 5, and 24 h) and performed functional analysis to identify pathways. Of note, female-specific pathways include T-helper cell differentiation and regulation of T cell activation. Canonical pathways and GO biological process for ≤ 3 h after stroke were shown here. In a mouse model of stroke, females had higher regulatory T cells in the blood compared with males [74] (created with BioRender.com)