TABLE 2.

Expression of βsp/^Aγ mRNA in μLCRβsp^Aγψβδβ and μLCR^Aγψβδβ transgenic mouse lines

Construct	Line	Mean human γ-globin RNA/ mouse α-globin RNA ± SD			Mean human β-globin RNA/ mouse α-globin RNA ± SD			Copy no.	Mean γ-globin RNA/transgene copy no. in adults	Mean β-globin RNA/transgene copy no. in adults
		Yolk sac	Fetal liver	Adult	Yolk sac	Fetal liver	Adult
μLCRβspAγψβδβ	A	0.47 ± 0.37	0.42 ± 0.11	0.46 ± 0.01	1.04 ± 0.83	2.70 ± 2.79	0.66 ± 0.33	15	0.12	0.18
	B	0.23	0.54 ± 0.17	0.55 ± 0.15	0.96	0.40 ± 0.22	1.34 ± 0.58	40	0.06	0.13
	C	ND	ND	0.31	ND	ND	0.71	8	0.16	0.36
Mean ± SD		0.39 ± 0.29	0.48 ± 0.15	0.48 ± 0.14	1.01 ± 0.59	1.32 ± 1.88	1.01 ± 0.54		0.11 ± 0.05	0.22 ± 0.12
μLCRAγψβδβ	A	ND	0.16	0.06	0.00	0.52	0.64	34	0.01	0.08
	B	1.06 ± 1.10	0.05 ± 0.07	0.03 ± 0.01	0.02 ± 0.01	0.18 ± 0.25	0.53 ± 0.04	20	0.01	0.11
	C	1.54 ± 1.73	0.05 ± 0.01	0.04 ± 0.00	0.04 ± 0.04	0.20 ± 0.06	0.49 ± 0.41	4	0.04	0.49
Mean ± SD		1.30 ± 1.22	0.07 ± 0.06	0.04 ± 0.01	0.02 ± 0.03	0.26 ± 0.20	0.53 ± 0.021		0.02 ± 0.02	0.23 ± 0.23