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. 2024 Mar 9;10:125. doi: 10.1038/s41420-024-01901-y

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — A, B Determination of cytotoxicity after 72 h treatment with meriolin 16 and 36 or imatinib in (A) imatinib-sensitive (K562 _Imat-S) and -resistant (K562 _Imat-R) K562 chronic myeloid leukemia (CML) cells or B imatinib-sensitive (KCL22 _Imat-S) and -resistant (KCL22 _Imat-R) KCL22 CML cells. Cell viability was assessed by AlamarBlue® assay. Respective IC₅₀ values are shown in parenthesis. Data shown are the mean ± SD from one (n = 1) experiment, performed in triplicates (n = 3). C Determination of cytotoxicity after 72 h treatment with meriolin 16 and 36 or cisplatin in cisplatin-sensitive (J82_Cisp-S) and -resistant (J82_Cisp-R) J82 urothelial carcinoma cells. Cell viability was assessed by AlamarBlue® assay. Respective IC₅₀ values are shown in parenthesis. Data shown are the mean ± SD from three independent (n = 3) experiments, each performed in quadruplicate (n = 4). D Kinetics of cytotoxicity upon treatment with 1 µM cisplatin, meriolin 16 or 36 of cisplatin-sensitive (2102EP_Cisp-S) and -resistant (2102EP_Cisp-R) 2102EP germ cell tumor cells. Cell viability was assessed by XTT assay.