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Schematic mechanisms of pyroptosis-dependent cell death in the course of the pathogenesis of DWH. Hyperglycemia, insulin resistance and hyperlipidemia stimulate NLRP3/ASC inflammasome signals, further activating pro-caspase-1 into Caspase-1 form. Then, activated Caspase-1 induces pyroptosis and the generation of inflammatory factors including IL-1β and IL-18, resulting in low-grade inflammation and extensive tissue damage, eventually advancing DWH.
