Table 1.
Compounds/Agents Targeting Pyroptosis-Related Signaling Pathways for the Therapeutic Regulation of DWH
| Compounds/Agents | Targeting of Inhibiting Pyroptosis-Related Signaling Pathways | References |
|---|---|---|
| Disulfiram | NLRP3/Caspase-1/GSDMD/IL-1β and IL-18 | [23] |
| HF-MCSs | NLRP3/ Caspase-1/IL-18/IL-1β | [125] |
| BMMSC-CM | NLRP3/Caspase-1/GSDMD/IL-1β and IL-18 | [81] |
| Tubastatin A | NLRP3/Caspase-1/ IL-1β | [136] |
| PKR inhibitor C16 | NLRP3/IL-1β | [83] |
| Calcitriol | NLRP3/IL-1β | [137] |
| MF-094 | NLRP3/ Caspase-1/IL-18/IL-1β | [138] |
| Metformin | NOXS/ROS/NLRP3 | [139] |
| Bletilla striata polysaccharide | NLRP3/IL-1β | [140] |
| Heparin sulfate | NLRP3/IL-1β and IL-18 | [141] |
| Sanguisorba officinalis extract | NF-κB/NLRP3/ Caspase-1/IL-1β and IL-18 | [142] |
| Genistein | NF-κB/ASC/NLRP3/Caspase-1 | [143] |
| UC-MSCs | NLRP3/Cleaved Caspase-1/GSDMD/IL-1β/IL-18 | [144] |
| Rapamycin | ROS/NF-κB/NLRP3 | [145] |
| Paeoniflorin | TLR2/ NF-κB/NLRP3/IL-1β | [146] |
| WB800N | TLR2/NLRP3/ASC/Caspase-1/IL-1β | [147] |
| Glyburide | ROS/ NLRP3/Caspase-1/ | [11] |
| Ac-YVAD-cmk | Caspase-1/NLRP3/ IL-1β/ IL-1β | [11] |
| Bay 11–7082 | ROS/TXNIP/NLRP3/Caspase-1/ IL-1β | [67] |
| MCC950 | NLPR3/Caspase-1/IL-1β/18 | [137] |