Table 1:
Characteristics of Donors in the Mayo Clinic Salivary Regenerative Biobanking
| Characteristics | All Patients N = 167 (100%) |
Male N = 94 (100%) |
Female N = 73 (100%) |
|---|---|---|---|
| Sex Assigned at Birth | |||
| Male | 94 (56.3%) | 94 (100%) | |
| Female | 73 (44.8%) | 73(100%) | |
| Vital Status | |||
| Deceased | 80 (47.9%) | 42 (44.7%) | 38 (52.1%) |
| Alive | 87 (52.1%) | 52 (55.3%) | 35 (47.9%) |
| Age | |||
| Median (range) | 69 (9–96) | 69.5 (9–96) | 69 (35–96) |
| Distribution | |||
| <45 | 13 (7.8%) | 7 (7.4%) | 6 (8.2%) |
| 45–60 | 36 (21.6%) | 21 (22.3%) | 15 (20.5%) |
| >60 | 118 (70.7%) | 66 (70.2%) | 52 (71.2%) |
| Menopausal Status (Female only) | |||
| Premenopausal | — | — | 4 (5.5%) |
| Perimenopausal | — | — | 0 (0.0%) |
| Postmenopausal | — | — | 45 (61.6%) |
| Unknown | — | — | 24 (32.9%) |
| Pregnancy | |||
| Never | — | — | 14 (19.2%) |
| 1–2 | — | — | 13 (17.8%) |
| >2 | — | — | 15 (20.5%) |
| Unknown | — | — | 31 (42.5%) |
| BMI | |||
| <16 | 3 (1.8%) | 3 (3.2%) | 0 (0.0%) |
| 16–25 | 48 (28.7%) | 26 (27.7%) | 22 (30.1%) |
| 25–30 | 43 (25.7%) | 26 (27.7%) | 17 (23.3%) |
| >30 | 64 (38.3%) | 35 (37.2%) | 29 (39.7%) |
| Unknown | 9 (5.4%) | 4 (4.3%) | 5 (6.8%) |
| Race/Ethnicity | |||
| White | 151 (90.4%) | 85 (90.4%) | 66 (90.4%) |
| Hispanic/Latino | 1 (0.6%) | 1 (1.1%) | 0 (0.0%) |
| Black/African American | 4 (2.4%) | 2 (2.1%) | 2 (2.7%) |
| Native American/American Indian | 2 (1.2%) | 1 (1.1%) | 1 (1.4%) |
| Asian/Pacific Islander | 1 (0.6%) | 1 (1.1%) | 0 (0.0%) |
| Other | 1 (0.6%) | 0 (0.0%) | 1 (1.4%) |
| Unknown | 7 (4.2%) | 4 (4.3%) | 3 (4.1%) |
| Surgery (N = Total Alive) | 87 | 52 | 35 |
| Unilateral partial parotidectomy | 49 (56.3%) | 30 (57.7%) | 19 (54.3%) |
| Unilateral total parotidectomy | 27 (31.0%) | 15 (28.8%) | 12 (34.3%) |
| Unilateral submandibulectomy | 8 (9.2%) | 5 (9.6%) | 3 (8.6%) |
| Bilateral submandibulectomy | 3 (3.4%) | 2 (3.8%) | 1 (2.9%) |
| Autopsy (N = Total Deceased) | 80 | 42 | 38 |
| Bilateral submandibulectomy | 79 (98.7%) | 41 (97.6%) | 38 (100.0%) |
| Unilateral submandibulectomy | 1 (1.3%) | 1 (2.4%) | 0 (0.0%) |
| Cause of Death (N = Total Deceased) | 80 | 42 | 38 |
| Cardiovascular | 39 (48.8%) | 20 (47.6%) | 19 (50.0%) |
| Other organs* | 26 (32.5%) | 13 (31.0%) | 13 (34.2%) |
| Cancer | 20 (25.0%) | 6 (14.3%) | 14 (36.8%) |
| CNS | 14 (17.5%) | 8 (19.0%) | 6 (15.8%) |
| Infections (excluding Covid) | 13 (16.3%) | 5 (11.9%) | 8 (21.1%) |
| Diabetes | 13 (16.3%) | 8 (19.0%) | 5 (13.2%) |
| Covid | 10 (12.5%) | 5 (11.9%) | 5 (13.2%) |
| Unknown# | 5 (6.3%) | 3 (7.1%) | 2 (5.3%) |
| Blunt force injuries | 4 (5.0%) | 2 (4.8%) | 2 (5.3%) |
| Sialagogue Usage | |||
| Pilocarpine | 1 (0.6%) | 1 (1.1%) | 0 (0.0%) |
| Cevimeline | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| No | 162 (97.0%) | 90 (95.7%) | 72 (98.8%) |
| Unknown | 4 (2.4%) | 3 (3.2%) | 1 (1.4%) |
| Chronic Diseases | |||
| Rheumatoid arthritis | 6 (3.6%) | 3 (3.2%) | 3 (4.1%) |
| Sjögren’s syndrome | 1 (0.6%) | 0 (0.0%) | 1 (1.4%) |
| Systemic lupus erythematosus | 1 (0.6%) | 0 (0.0%) | 1 (1.4%) |
| Primary biliary cirrhosis | 4 (2.4%) | 2 (2.1%) | 2 (2.7%) |
| Diabetes mellitus | 34 (20.4%) | 21 (22.3%) | 13 (17.8%) |
| Thyroiditis | 1 (0.6%) | 0 (0.0%) | 1 (1.4%) |
| None | 118 (70.7%) | 66 (70.2%) | 52 (71.2%) |
| Unknown | 5 (3.0%) | 3 (3.2%) | 2 (2.7%) |
| History of Cancer | |||
| Yes | 70 (41.9%) | 40 (42.6%) | 30 (41.1%) |
| No | 93 (55.7%) | 51 (54.3%) | 42 (57.5%) |
| Unknown | 4 (2.4%) | 3 (3.2%) | 1 (1.4%) |
| History of Head & Neck Radiotherapy | |||
| Yes | 17 (10.2%) | 11 (11.7%) | 6 (8.2%) |
| No | 144 (86.2%) | 79 (84.0%) | 65 (89.0%) |
| Unknown | 6 (3.6%) | 4 (4.3%) | 2 (2.7%) |
| History of Chemotherapy | |||
| Yes | 27 (16.2%) | 15 (16.0%) | 12 (16.4%) |
| No | 135 (80.8%) | 76 (80.9%) | 59 (80.8%) |
| Unknown | 5 (3.0%) | 3 (3.2%) | 2 (2.7%) |
| Number of Medications | |||
| None | 6 (3.6%) | 2 (2.1%) | 4 (5.5%) |
| 1–3 | 19 (11.4%) | 11 (11.7%) | 8 (11.0%) |
| 4–6 | 23 (13.8%) | 10 (10.6%) | 13 (17.8%) |
| >6 | 116 (69.5%) | 69 (73.4%) | 47 (64.4%) |
| Unknown | 3 (1.8%) | 2 (2.1%) | 1 (1.4%) |
| Salivary Gland Neoplasm | |||
| Warthin’s tumor | 2 (1.2%) | 2 (2.1%) | 0 (0.0%) |
| Mucoepidermoid carcinoma | 1 (0.6%) | 0 (0.0%) | 1 (1.4%) |
| None | 160 (95.8%) | 90 (95.7%) | 70 (95.9%) |
| Unknown | 4 (2.4%) | 2 (2.1%) | 2 (2.7%) |
| History of Covid-19 | |||
| Yes | 33 (19.8%) | 20 (21.3%) | 13 (17.8%) |
| No | 95 (56.9%) | 56 (59.6%) | 39 (53.4%) |
| Unknown | 39 (23.4%) | 24 (25.5%) | 15 (20.5%) |
| Neuropathy | |||
| Parkinson | 4 (2.4%) | 4 (4.3%) | 0 (0.0%) |
| Alzheimer | 4 (2.4%) | 4 (4.3%) | 0 (0.0%) |
| Multiple sclerosis | 1 (0.6%) | 0 (0.0%) | 1 (1.4%) |
| None | 154 (92.2%) | 84 (89.4%) | 70 (95.9%) |
| Unknown | 4 (2.4%) | 2 (2.1%) | 2 (2.7%) |
| Chronic Infections | |||
| HCV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| HIV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| EBV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| CMV | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) |
| None | 162 (97.0%) | 91 (96.8%) | 71 (97.3%) |
| Unknown | 5 (3.0%) | 3 (3.2%) | 2 (2.7%) |
| Smoking | |||
| Current | 26 (15.6%) | 15 (16.0%) | 11 (15.1%) |
| Former | 61 (36.5%) | 37 (39.4%) | 24 (32.9%) |
| Never | 72 (43.1%) | 39 (41.5%) | 33 (45.4%) |
| Unknown | 8 (4.8%) | 3 (3.2%) | 5 (6.8%) |
*
Other organs include Lung, kidney, liver, and pancreas.
#
Cause of death unknown at the time of the autopsy