Figure 2. Accuracy for fusion transcript detection using simulated long reads.

(a) Scheme for criteria in benchmarking fusion detection. (b) Accuracy reported as maximum F1 score determined using simulated PacBio and ONT long reads with moderate to high error rates (test data derived from [Jaffal paper ref]. (c) Accuracy using pbsim3 simulated PacBio HiFi or ONT R10.4.1 isoform reads at 50x coverage additionally focused on breakpoint resolution, with mean of maximum F1 values across 5 samples of 500 different target fusions each.