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. 1998 Nov;18(11):6679–6697. doi: 10.1128/mcb.18.11.6679

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Copyright © 1998, American Society for Microbiology

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FIG. 4 — Sequence and schematic representation of the human CDC6 promoter. (A) Nucleotide sequence of the 1,759-bp CDC6 promoter. The previously reported 355-bp fragment is underlined (79). Three putative E2F DNA-binding sites are boxed. A putative CHR region (bp −30 to −26) and the putative INR region (bp −16 to −11) are shown in lowercase. Restriction sites used for cloning are italic, and the transcription start site (bp +1) is bold. (B) Schematic representation of transcription factor-binding sites in the large 1,759-bp human CDC6 promoter. The transcription start site is depicted with an arrow. A CHR site, a CCAAT box, and a putative Sp1 element (Sp1/?) which are found to be protected in in vivo footprint assays, are located next to the two 3′ E2F sites close to the start site. Positions of consensus binding sites for AP-2, C/EBP, Ets-1, and NF-κB are also given. Putative recognition sites upstream of bp −325 and downstream of the start site are not shown. INR, initiator region.

FIG. 4 — Sequence and schematic representation of the human CDC6 promoter. (A) Nucleotide sequence of the 1,759-bp CDC6 promoter. The previously reported 355-bp fragment is underlined (79). Three putative E2F DNA-binding sites are boxed. A putative CHR region (bp −30 to −26) and the putative INR region (bp −16 to −11) are shown in lowercase. Restriction sites used for cloning are italic, and the transcription start site (bp +1) is bold. (B) Schematic representation of transcription factor-binding sites in the large 1,759-bp human CDC6 promoter. The transcription start site is depicted with an arrow. A CHR site, a CCAAT box, and a putative Sp1 element (Sp1/?) which are found to be protected in in vivo footprint assays, are located next to the two 3′ E2F sites close to the start site. Positions of consensus binding sites for AP-2, C/EBP, Ets-1, and NF-κB are also given. Putative recognition sites upstream of bp −325 and downstream of the start site are not shown. INR, initiator region.