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Genetic inactivation of Sar1b leads to perinatal lethality
| Mating Genotype Expected |
Sar1b+/− X Sar1b+/− |
p-value (χ2 test) | ||
|---|---|---|---|---|
| Sar1b+/+ 25% | Sar1b+/− 50% | Sar1b−/− 25% | ||
|
| ||||
| E11.5 | 3 (19%) | 8 (50%) | 4 (31%) | 0.779 |
| E18.5 | 14 (26%) | 24 (44%) | 16 (30%) | 0.665 |
| P0 | 4 (31%) | 7 (54%) | 2 (15%) | 0.707 |
| P1 | 4 (57%) | 3 (43%) | 0 (0%) | 0.095 |
| Weaning (P21) | 29 (35%) | 54 (65%) | 0 (0%) | 9.21 x 10−7 |
