Table 2.

The correlation strength (R) and p-value of Spearman correlation between IC₅₀ values and optimal growth temperature of the heat-evolved strains. Significant correlations (p < 0.05) are shown in bold. These results show that IC₅₀ values and optimal growth temperature are mostly independent of one another across antibiotics.

Drug	Temperature (°C)	# of Strains	Spearman Correlation (R)	p-value
AMP	37	108	−0.061	0.55
CLI	37	108	0.12	0.23
CPR	37	108	0.025	0.81
ERY	37	108	0.2	0.047
FOX	37	108	0.052	0.61
GEN	37	108	−0.0035	0.73
LVX	37	108	−0.13	0.19
NTR	37	108	0.22	0.032
STR	37	108	0.099	0.45
TET	37	108	−0.0042	0.97
TMP	37	108	0.17	0.094
TOB	37	108	0.12	0.23
AMP	42	15	−0.14	0.63
CLI	42	15	0.17	0.54
CPR	42	15	0.14	0.62
ERY	42	15	0.11	0.7
FOX	42	15	0.086	0.76
GEN	42	15	0.61	0.017
LVX	42	15	0.42	0.12
NTR	42	15	0.34	0.21
STR	42	15	0.16	0.58
TET	42	15	−0.027	0.93
TMP	42	15	0.14	0.63
TOB	42	15	0.66	0.0086