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[Preprint]. 2024 Feb 28:2024.02.28.582557. [Version 1] doi: 10.1101/2024.02.28.582557

Table 2.

Plasmids used in this study. All genes are Homo sapiens unless indicated otherwise. The relevant amino acid residues are noted and colored accordingly. Mutations are described by the position of the residues in the full-length protein and are highlighted in the sequence. Gray amino acid sequences indicate linkers.

Shorthand Name Full Name Reference Sequence
NES-PABD-Spo20 X.leavis map2k1.L32-44-EGFP-S. cerevisiae Spo20p51-91 (Zeniou-Meyer et al., 2007; Zhang et al., 2014) MALQKKLEELELDEAPVATMVSKGEELFTGVVPILVELDGDVNGHK
FSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFS
RYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEG
DTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKV
NFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSK
DPNEKRDHMVLLEFVTAAGITLGMDELYKGLRSRASIMDNCSGSR
RRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTS*
PASS EGFP-M. musculus PKIa34-51-S. cerevisiae Spo20p51-91 (Zhang et al., 2014; Zeniou-Meyer et al., 2007) MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMP
EGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNI
LGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHY
QQNTPIGDGPVLLPDNHYLSTQSKLSKDPNEKRDHMVLLEFVTAA
GITLGMDELYKSGLRSRANSNELALKLAGLDINKTESRMDNCSASR
RRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTS*
NES-flex-PABD-Spo20 X.leavis map2k1.L32-44-EGFP-SGGGSGGS-S. cerevisiae Spo20p51-91 This Study MALQKKLEELELDEAPVATMVSKGEELFTGVVPILVELDGDVNGHK
FSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFS
RYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEG
DTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKV
NFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSK
DPNEKRDHMVLLEFVTAAGITLGMDELYKSGGGSGGSMDNCSGS
RRRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTS*
NES-PABDx2-Spo20 X.leavis map2k1.L32-44-EGFP-S. cerevisiae Spo20p51-91- S. cerevisiae Spo20p51-91 (Bohdanowicz et al., 2013) MALQKKLEELELDEAPVATMVSKGEELFTGVVPILVELDGDVNGHK
FSVSGEGEGDATYGKLTLKFICTTGKLPVPWPTLVTTLTYGVQCFS
RYPDHMKQHDFFKSAMPEGYVQERTIFFKDDGNYKTRAEVKFEG
DTLVNRIELKGIDFKEDGNILGHKLEYNYNSHNVYIMADKQKNGIKV
NFKIRHNIEDGSVQLADHYQQNTPIGDGPVLLPDNHYLSTQSALSK
DPNEKRDHMVLLEFVTAAGITLGMDELYKSGLRSRAMDNCSGSRR
RDRLHVKLKSLRNKIHKQLHPNCRFDDATKTSMDNCSGSRRRDRL
HVKLKSLRNKIHKQLHPNCRFDDATKTS*
NESx2-PABDx2-Spo20 X.leavis map2k1.L32-44-X.leavis map2k1.L32-44-EGFP-S. cerevisiae Spo20p51-91- S. cerevisiae Spo20p51-91 This Study MALQKKLEELELDEAGGSGMALQKKLEELELDEAPVATMVSKGEE
LFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICTTGKL
PVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYVQERTI
FFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNY
NSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNTPIGDG
PVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITLGMDELY
KSGLRSRAMDNCSGSRRRDRLHVKLKSLRNKIHKQLHPNCRFDDA
TKTSMDNCSGSRRRDRLHVKLKSLRNKIHKQLHPNCRFDDATKTS*
Nir1-LNS2 NeonGreen-Nir1613-897 This Study MVSKGEEDNMASLPATHELHIFGSINGVDFDMVGQGTGNPNDGY
EELNLKSTKGDLQFSPWILVPHIGYGFHQYLPYPDGMSPFQAAMV
DGSGYQVHRTMQFEDGASLTVNYRYTYEGSHIKGEAQVKGTGFP
ADGPVMTNSLTAADWCRSKKTYPNDKTIISTFKWSYTTGNGKRYR
STARTTYTFAKPMAANYLKNQPMYVFRKTELKHSKTELNFKEWQK
AFTDVMGMDELYKGGSGGMPANPREKWLRKRTQVKLRNVTANH
RANDVIAAEDGPQVLVGRFMYGPLDMVALTGEKVDILVMAEPSSG
RWVHLDTEITNSSGRITYNVPRPRRLGVGVYPVKMVVRGDQTCAM
SYLTVLPRGMECVVFSIDGSFAASVSIMGSDPKVRPGAVDVVRHW
QDLGYMILYITGRPDMQKQRVVSWLSQHNFPQGMIFFSDGLVHDP
LRQKAIFLRNLMQECFIKISAAYGSTKDISVYSVLGLPASQIFIVGRPT
KKYQTQCQFLSEGYAAHLAALEASHRSRPKKN*
Nir2-LNS2 NeonGreen-Nir2896-1216 This Study MVSKGEEDNMASLPATHELHIFGSINGVDFDMVGQGTGNPNDGY
EELNLKSTKGDLQFSPWILVPHIGYGFHQYLPYPDGMSPFQAAMV
DGSGYQVHRTMQFEDGASLTVNYRYTYEGSHIKGEAQVKGTGFP
ADGPVMTNSLTAADWCRSKKTYPNDKTIISTFKWSYTTGNGKRYR
STARTTYTFAKPMAANYLKNQPMYVFRKTELKHSKTELNFKEWQK
AFTDVMGMDELYKGGSGGMSPAFPREKWQRKRTQVKIRNVTSNH
RASDTVVCEGRPQVLSGRFMYGPLDVVTLTGEKVDVYIMTQPLSG
KWIHFGTEVTNSSGRLTFPVPPERALGIGVYPVRMVVRGDHTYAE
CCLTVVARGTEAVVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHW
QDSGYLIVYVTGRPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHD
PLRQKAMFLQSLVQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIV
GRAVRKLQAQCQFLSDGYVAHLGQLEAGSHSHASSGPPRAALGK
SSYGVAAPVDFLRKQSQLLRSRGPSQA*
Nir3-LNS2 mEGFP-Nir3925-1209 This Study MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMP
EGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNI
LGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHY
QQNTPIGDGPVLLPDNHYLSTQSKLSKDPNEKRDHMVLLEFVTAA
GITLGMDELYKGGGGSHMPSKPREKWQRKRTHVKLRNVTANHRI
NDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGE
WLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSY
ITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDL
GYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRH
KANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKK
LQQQCQFITDGYAAHLAQLKYSHRARPARN*
Nir1-613-630 Nir1613-630-NeonGreen This Study MPANPREKWLRKRTQVKLRGGSGGMVSKGEEDNMASLPATHEL
HIFGSINGVDFDMVGQGTGNPNDGYEELNLKSTKGDLQFSPWILV
PHIGYGFHQYLPYPDGMSPFQAAMVDGSGYQVHRTMQFEDGASL
TVNYRYTYEGSHIKGEAQVKGTGFPADGPVMTNSLTAADWCRSK
KTYPNDKTIISTFKWSYTTGNGKRYRSTARTTYTFAKPMAANYLKN
QPMYVFRKTELKHSKTELNFKEWQKAFTDVMGMDELYK*
Nir1-631-894 Nir1631-894-NeonGreen This Study MVSKGEEDNMASLPATHELHIFGSINGVDFDMVGQGTGNPNDGY
EELNLKSTKGDLQFSPWILVPHIGYGFHQYLPYPDGMSPFQAAMV
DGSGYQVHRTMQFEDGASLTVNYRYTYEGSHIKGEAQVKGTGFP
ADGPVMTNSLTAADWCRSKKTYPNDKTIISTFKWSYTTGNGKRYR
STARTTYTFAKPMAANYLKNQPMYVFRKTELKHSKTELNFKEWQK
AFTDVMGMDELYKGGSGGNVTANHRANDVIAAEDGPQVLVGRFM
YGPLDMVALTGEKVDILVMAEPSSGRWVHLDTEITNSSGRITYNVP
RPRRLGVGVYPVKMVVRGDQTCAMSYLTVLPRGMECVVFSIDGS
FAASVSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQR
VVSWLSQHNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKISA
AYGSTKDISVYSVLGLPASQIFIVGRPTKKYQTQCQFLSEGYAAHLA
ALEASHRSRP*
C1ab-Prkd1 X.leavis map2k1.L32-44-mCherry-M. musculus Prkd1138-343 (Kim et al., 2011) MALQKKLEELELDEAPVATMVSKGEEDNMAIIKEFMRFKVHMEGS
VNGHEFEIEGEGEGRPYEGTQTAKLKVTKGGPLPFAWDILSPQFM
YGSKAYVKHPADIPDYLKLSFPEGFKWERVMNFEDGGVVTVTQDS
SLQDGEFIYKVKLRGTNFPSDGPVMQKKTMGWEASSERMYPEDG
ALKGEIKQRLKLKDGGHYDAEVKTTYKAKKPVQLPGAYNVNIKLDIT
SHNEDYTIVEQYERAEGRHSTGGMDELYKSGLRSRAQASNSTSED
FQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQGLKCEGCGLNYH
KRCAFKIPNNCSGVRRRRLSNVSLTGLGTVRTASAEFSTSVPDEPL
LSPVSPGFEQKSPSESFIGREKRSNSQSYIGRPIQLDKLLMSKVKV
PHTFVIHSYTRPTVCQFCKKLLKGLFRQGLQCKDCRFNCHKRCAP
KVPNNCLGEVTINGELLSPGAES*
FKBP-PJ-Dead mCherry-FKBP1A3-109-S. cerevisiae Sac12-517, C392S - INPP5E214-644, D556A,C641A (Hammond et al., 2012) MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEG
TQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLS
FPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPS
DGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDA
EVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHS
TGGMDELYKSGLRSRSAAAGAGGAARAALGVQVETISPGDGRTFP
KRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWE
EGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
SAGGSAGGSAGGSAGGSAGGPRAQASRSLDATGPIVYVQNADGI
FFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLM
GFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSE
EAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADE
RFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIV
LGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKI
HVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQK
ELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFH
HECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQ
HSVVRTN[S]MDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTW
EDNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLG
AFNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFP
GGTARGAAAGAGGAGRSDLADYKLRAQPLLVRAHSSLGPGRPRS
PLACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGA
DELARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQD
LYVIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIR
RDLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTS
GDGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEV
FWFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKG
SIFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYT[A]RVLYRSR
HKGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKF
DRELYLLGIKRRISKEIQRQQALQSQNSSTI[A]SVS*
FKBP-PJ mCherry-FKBP1A3-109-S. cerevisiae Sac12-517- INPP5E214-644, C641A (Hammond et al., 2012) MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEG
TQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLS
FPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPS
DGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDA
EVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHS
TGGMDELYKSGLRSRSAAAGAGGAARAALGVQVETISPGDGRTFP
KRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWE
EGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
SAGGSAGGSAGGSAGGSAGGPRAQASRSLDATGPIVYVQNADGI
FFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLM
GFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSE
EAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADE
RFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIV
LGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKI
HVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQK
ELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFH
HECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQ
HSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWE
DNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGA
FNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPG
GTARGAAAGAGGAGRSDLADYKLRAQPLLVRAHSSLGPGRPRSP
LACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGAD
ELARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDL
YVIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIRR
DLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSG
DGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVF
WFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGS
IFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHK
GDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDR
ELYLLGIKRRISKEIQRQQALQSQNSSTI[A]SVS*
FKBP-INPP5E mCherry-FKBP1A3-109-INPP5E214-644, C641A (Hammond et al., 2012) MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEG
TQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLS
FPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPS
DGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDA
EVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHS
TGGMDELYKSGLRSRSAAAGAGGAARAAMGVQVETISPGDGRTF
PKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
ARGAAAGAGGAGRSDLADYKLRAQPLLVRAHSSLGPGRPRSPL
ACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGADE
LARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDLY
VIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIRR
DLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSG
DGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVF
WFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGS
IFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYRSRHK
GDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDR
ELYLLGIKRRISKEIQRQQALQSQNSSTI[A]SVS*
FKBP-Sac1 mCherry-FKBP1A3-109-S. cerevisiae Sac12-517-INPP5E214-644, D556A C641A (Hammond et al., 2012) MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEG
TQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLS
FPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPS
DGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDA
EVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHS
TGGMDELYKSGLRSRSAAAGAGGAARAALGVQVETISPGDGRTFP
KRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWE
EGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
SAGGSAGGSAGGSAGGSAGGPRAQASRSLDATGPIVYVQNADGI
FFKLAEGKGTNDAVIHLANQDQGVRVLGAEEFPVQGEVVKIASLM
GFIKLKLNRYAIIANTVEETGRFNGHVFYRVLQHSIVSTKFNSRIDSE
EAEYIKLLELHLKNSTFYFSYTYDLTNSLQRNEKVGPAASWKTADE
RFFWNHYLTEDLRNFAHQDPRIDSFIQPVIYGYAKTVDAVLNATPIV
LGLITRRSIFRAGTRYFRRGVDKDGNVGNFNETEQILLAENPESEKI
HVFSFLQTRGSVPIYWAEINNLKYKPNLVLGENSLDATKKHFDQQK
ELYGDNYLVNLVNQKGHELPVKEGYESVVHALNDPKIHYVYFDFH
HECRKMQWHRVKLLIDHLEKLGLSNEDFFHKVIDSNGNTVEIVNEQ
HSVVRTNCMDCLDRTNVVQSVLAQWVLQKEFESADVVATGSTWE
DNAPLLTSYQNLWADNADAVSVAYSGTGALKTDFTRTGKRTRLGA
FNDFLNSASRYYQNNWTDGPRQDSYDLFLGGFRPHTASIKSPFPG
GTARGAAAGAGGAGRSDLADYKLRAQPLLVRAHSSLGPGRPRSP
LACDDCSLRSAKSSFSLLAPIRSKDVRSRSYLEGSLLASGALLGAD
ELARYFPDRNVALFVATWNMQGQKELPPSLDEFLLPAEADYAQDL
YVIGVQEGCSDRREWETRLQETLGPHYVLLSSAAHGVLYMSLFIRR
DLIWFCSEVECSTVTTRIVSQIKTKGALGISFTFFGTSFLFITSHFTSG
DGKVAERLLDYTRTVQALVLPRNVPDTNPYRSSAADVTTRFDEVF
WFGDFNFRLSGGRTVVDALLCQGLVVDVPALLQHDQLIREMRKGS
IFKGFQEPDIHFLPSYKFDIGKDTYDSTSKQRTPSYT[A]RVLYRSRH
KGDICPVSYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFD
RELYLLGIKRRISKEIQRQQALQSQNSSTI[A]SVS*
PM-FRB Lyn1-11-MTOR2021-2113-iRFP
(Hammond et al., 2014)
MGCIKSKGKDSRSANSGAGAGAGAILSRILWHEMWHEGLEEASRL
YFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEA
QEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKTSYPYDVPDYAP
VATMAEGSVARQPDLLTCDDEPIHIPGAIQPHGLLLALAADMTIVAG
SDNLPELTGLAIGALIGRSAADVFDSETHNRLTIALAEPGAAVGAPIT
VGFTMRKDAGFIGSWHRHDQLIFLELEPPQRDVAEPQAFFRRTNS
AIRRLQAAETLESACAAAAQEVRKITGFDRVMIYRFASDFSGEVIAE
DRCAEVESKLGLHYPASTVPAQARRLYTINPVRIIPDINYRPVPVTP
DLNPVTGRPIDLSFAILRSVSPVHLEFMRNIGMHGTMSISILRGERL
WGLIVCHHRTPYYVDLDGRQACELVAQVLAWQIGVMEE*
Mito-FRB iRFP-MTOR2021-2113-Fis122-152
(Doyle et al., 2023)
MAEGSVARQPDLLTCDDEPIHIPGAIQPHGLLLALAADMTIVAGSDN
LPELTGLAIGALIGRSAADVFDSETHNRLTIALAEPGAAVGAPITVGF
TMRKDAGFIGSWHRHDQLIFLELEPPQRDVAEPQAFFRRTNSAIRR
LQAAETLESACAAAAQEVRKITGFDRVMIYRFASDFSGEVIAEDRC
AEVESKLGLHYPASTVPAQARRLYTINPVRIIPDINYRPVPVTPDLNP
VTGRPIDLSFAILRSVSPVHLEFMRNIGMHGTMSISILRGERLWGLIV
CHHRTPYYVDLDGRQACELVAQVLAWQIGVMEESGLRSRAGGAG
AILSRILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMER
GPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDL
YYHVFRRISKGGSAGGSAQASNSAVDGTAGLVGMAIVGGMALGV
AGLAGLIGLAVSKSKS*
FKBP-PI4K mCherry-FKBP1A3-108-PI4KA1102-2103 (Zewe et al., 2020) MVSKGEEDNMAIIKEFMRFKVHMEGSVNGHEFEIEGEGEGRPYEG
TQTAKLKVTKGGPLPFAWDILSPQFMYGSKAYVKHPADIPDYLKLS
FPEGFKWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPS
DGPVMQKKTMGWEASSERMYPEDGALKGEIKQRLKLKDGGHYDA
EVKTTYKAKKPVQLPGAYNVNIKLDITSHNEDYTIVEQYERAEGRHS
TGGMDELYKSGLRSRSAAAGAGGAARAALGVQVETISPGDGRTFP
KRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWE
EGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
SAGGSAGGSAGGSAGGSAGGPRAQASNSMATESILHFAGYNKQN
TTLGATQLSERPACVKKDYSNFMASLNLRNRYAGEVYGMIRFSGT
TGQMSDLNKMMVQDLHSALDRSHPQHYTQAMFKLTAMLISSKDC
DPQLLHHLCWGPLRMFNEHGMETALACWEWLLAGKDGVEVPFM
REMAGAWHMTVEQKFGLFSAEIKEADPLAASEASQPKPCPPEVTP
HYIWIDFLVQRFEIAKYCSSDQVEIFSSLLQRSMSLNIGGAKGSMNR
HVAAIGPRFKLLTLGLSLLHADVVPNATIRNVLREKIYSTAFDYFSCP
PKFPTQGEKRLREDISIMIKFWTAMFSDKKYLTASQLVPPDNQDTR
SNLDITVGSRQQATQGWINTYPLSSGMSTISKKSGMSKKTNRGSQ
LHKYYMKRRTLLLSLLATEIERLITWYNPLSAPELELDQAGENSVAN
WRSKYISLSEKQWKDNVNLAWSISPYLAVQLPARFKNTEAIGNEVT
RLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPT
GLSYFSSMYPPHPLTAQYGVKVLRSFPPDAILFYIPQIVQALRYDKM
GYVREYILWAASKSQLLAHQFIWNMKTNIYLDEEGHQKDPDIGDLL
DQLVEEITGSLSGPAKDFYQREFDFFNKITNVSAIIKPYPKGDERKK
ACLSALSEVKVQPGCYLPSNPEAIVLDIDYKSGTPMQSAAKAPYLA
KFKVKRCGVSELEKEGLRCRSDSEDECSTQEADGQKISWQAAIFK
VGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIE
CIPDCTSRDQLGRQTDFGMYDYFTRQYGDESTLAFQQARYNFIRS
MAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFMFESSPGDNLG
WEPDIKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDA
VVSLVTLMLDTGLPCFRGQTIKLLKHRFSPNMTEREAANFIMKVIQS
CFLSNRSRTYDMIQYYQNDIPY*
FKBP-PIP5K pTagBFP-FKBP1A3-108-PIP5K1C1-635, D101R, R304D, R445E, K446E This Study MVSELIKENMHMKLYMEGTVDNHHFKCTSEGEGKPYEGTQTMRIK
VVEGGPLPFAFDILATSFLYGSKTFINHTQGIPDFFKQSFPEGFTWE
RVTTYEDGGVLTATQDTSLQDGCLIYNVKIRGVNFTSNGPVMQKKT
LGWEAFTETLYPADGGLEGRNDMALKLVGGSHLIANAKTTYRSKK
PAKNLKMPGVYYVDYRLERIKEANNETYVEQHEVAVARYCDLPSK
LGHKLNSGLRSRSAAAGAGGAARAALGVQVETISPGDGRTFPKRG
QTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGV
AQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESAG
GSAGGSAGGSAGGSAGGPRAQASNSAVDLQAMELEVPDEAESA
EAGAVPSEAAWAAESGAAAGLAQKKAAPTEVLSMTAQPGPGHGK
KLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGHLSSKPER[R]
VLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRYFREL
FGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEA
EFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGGKNIRVVVMNNI
LPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPE
GLLLDADTFSALVKTLQ[D]DCLVLESFKIMDYSLLLGVHNIDQHERE
RQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDT
MGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVS
VHRPSFYAERFFKFMSNTVF[EE]NSSLKSSPSKKGRGGALLAVKPL
GPTAAFSASQIPSEREEAQYDLRGARSYPTLEDEGRPDLLPCTPPS
FEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGR
PQEEPPAEEDLQQITVQVEPACSVEIVVPKEEDAGVEASPAGASAA
VEVETASQASDEEGAPASQASDEEDAPATDIYF*
EGFP-PH-PLCd1 PLCd11-170-EGFP (Várnai and Balla, 1998) MDSGRDFLTLHGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQ
EDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARD
VPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMD
QRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKDPPVATMVSK
GEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTLKFICT
TGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMPEGYV
QERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHK
LEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHYQQNT
PIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAAGITLG
MDELYK*
FKBP-PI-PLC B. cereus PI-PLC32-329, W78A, W273A-FKBP1A3-108-TagBFP2 (Pemberton et al., 2020) MASSVNELENWSKWMQPIPDNIPLARISIPGTHDSGTFKLQNPIKQ
V[A]GMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVT
LHEFINEAKQFLRDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKNYF
VDPIFLKTEGNIKLGDARGKIVLLKRYSGSNESGGYNNFYWPDNET
FTTTVNQNVNVTVQDKYKVSYDEKVKSIKDTMNETMNNSEDLNHL
YINFTSLSSGGTA[A]NSPYYYASYINPEIANHIKQKNPARVGWVIQD
YINEKWSPLLYQEVIRANKSLIKERILQSTVPMGVQVETISPGDGRT
FPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRG
WEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELL
KLERDPPVATMVSELIKENMHMKLYMEGTVDNHHFKCTSEGEGKP
YEGTQTMRIKVVEGGPLPFAFDILATSFLYGSKTFINHTQGIPDFFK
QSFPEGFTWERVTTYEDGGVLTATQDTSLQDGCLIYNVKIRGVNFT
SNGPVMQKKTLGWEAFTETLYPADGGLEGRNDMALKLVGGSHLIA
NAKTTYRSKKPAKNLKMPGVYYVDYRLERIKEANNETYVEQHEVA
VARYCDLPSKLGHKLNSGLRSRSAAATLDHNQPYHICRGFTCFKK
PPTPPPEPET*
FKBP-DGKα mRFP-FKBP1A3-108-DGKA isoform b394-773 This Study MASSEDVIKEFMRFKVRMEGSVNGHEFEIEGEGEGRPYEGTQTAK
LKVTKGGPLPFAWDILSPQFQYGSKAYVKHPADIPDYLKLSFPEGF
KWERVMNFEDGGVVTVTQDSSLQDGEFIYKVKLRGTNFPSDGPV
MQKKTMGWEASTERMYPEDGALKGEIKMRLKLKDGGHYDAEVKT
TYMAKKPVQLPGAYKTDIKLDITSHNEDYTIVEQYERAEGRHSTGA
SGLRSRSAAAGAGGAARAALGVQVETISPGDGRTFPKRGQTCVV
HYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSV
GQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLESAGGSAGG
SAGGSAGGSAGGPRAQASRSDDLNLSTSEALRIDPVPNTHPLLVF
VNPKSGGKQGQRVLWKFQYILNPRQVFNLLKDGPEIGLRLFKDVP
DSRILVCGGDGTVGWILETIDKANLPVLPPVAVLPLGTGNDLARCLR
WGGGYEGQNLAKILKDLEMSKVVHMDRWSVEVIPQQTEEKSDPV
PFQIINNYFSIGVDASIAHRFHIMREKYPEKFNSRMKNKLWYFEFAT
SESIFSTCKKLEESLTVEICGKPLDLSNLSLEGIAVLNIPSMHGGSNL
WGDTRRPHGDIYGINQALGATAKVITDPDILKTCVPDLSDKRLEVV
GLEGAIEMGQIYTKLKNAGRRLAKCSEITFHTTKTLPMQIDGEPWM
QTPCTIKITHKNQMPMLMGPPPRSTNFFGFLS*
M3 pcDNA3.1-HAx3-AchR-CHRM32-590 J. Wess MYPYDVPDYAYPYDVPDYAYPYDVPDYADTLHNNSTTSPLFPNISS
SWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGH
TVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACA
DLIIGVISMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLV
ISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQ
YFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYK
ETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSMK
RSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAA
SLENSASSDEEDIGSETRAIYSIVLKLPGHSTILNSTKLPSSDNLQVP
EEELGMVDLERKADKLQAQKSVDDGGSFPKSFSKLPIQLESAVDT
AKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKRMSLV
KEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWL
CYINSTVNPVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQ
SVIFHKRAPEQAL*
GFP-Nir2 EGFP-PITPNM1v2 (Kim et al., 2015) MVSKGEELFTGVVPILVELDGDVNGHKFSVSGEGEGDATYGKLTL
KFICTTGKLPVPWPTLVTTLTYGVQCFSRYPDHMKQHDFFKSAMP
EGYVQERTIFFKDDGNYKTRAEVKFEGDTLVNRIELKGIDFKEDGNI
LGHKLEYNYNSHNVYIMADKQKNGIKVNFKIRHNIEDGSVQLADHY
QQNTPIGDGPVLLPDNHYLSTQSALSKDPNEKRDHMVLLEFVTAA
GITLGMDELYKSGLRSRAQASNSMLIKEYHILLPMSLDEYQVAQLY
MIQKKSREESSGEGSGVEILANRPYTDGPGGSGQYTHKVYHVGSH
IPGWFRALLPKAALQVEEESWNAYPYTRTRYTCPFVEKFSIEIETYY
LPDGGQQPNVFNLSGAERRQRILDTIDIVRDAVAPGEYKAEEDPRL
YHSVKTGRGPLSDDWARTAAQTGPLMCAYKLCKVEFRYWGMQA
KIEQFIHDVGLRRVMLRAHRQAWCWQDEWTELSMADIRALEEETA
RMLAQRMAKCNTGSEGSEAQPPGKPSTEARSAASNTGTPDGPEA
PPGPDASPDASFGKQWSSSSRSSYSSQHGGAVSPQSLSEWRMQ
NIARDSENSSEEEFFDAHEGFSDSEEVFPKEMTKWNSNDFIDAFAS
PVEAEGTPEPGAEAAKGIEDGAQAPRDSEGLDGAGELGAEACAVH
ALFLILHSGNILDSGPGDANSKQADVQTLSSAFEAVTRIHFPEALGH
VALRLVPCPPICAAAYALVSNLSPYSHDGDSLSRSQDHIPLAALPLL
ATSSSRYQGAVATVIARTNQAYSAFLRSPEGAGFCGQVALIGDGV
GGILGFDALCHSANAGTGSRGSSRRGSMNNELLSPEFGPVRDPLA
DGVEGLGRGSPEPSALPPQRIPSDMASPEPEGSQNSLQAAPATTS
SWEPRRASTAFCPPAASSEAPDGPSSTARLDFKVSGFFLFGSPLG
LVLALRKTVMPALEAQMRPACEQIYNLFHAADPCASRLEPLLAPKF
QAIAPLTVPRYQKFPLGDGSSLLLADTLQTHSSLFLEELEMLVPSTP
TSTSGAFWKGSELATDPPAQPAAPSTTSEVVKILERWWGTKRIDY
SLYCPEALTAFPTVTLPHLFHASYWESADVVAFILRQVIEKERPQLA
ECEEPSIYSPAFPREKWQRKRTQVKIRNVTSNHRASDTVVCEGRP
QVLSGRFMYGPLDVVTLTGEKVDVYIMTQPLSGKWIHFGTEVTNS
SGRLTFPVPPERALGIGVYPVRMVVRGDHTYAECCLTVVARGTEA
VVFSIDGSFTASVSIMGSDPKVRAGAVDVVRHWQDSGYLIVYVTG
RPDMQKHRVVAWLSQHNFPHGVVSFCDGLTHDPLRQKAMFLQSL
VQEVELNIVAGYGSPKDVAVYAALGLSPSQTYIVGRAVRKLQAQCQ
FLSDGYVAHLGQLEAGSHSHASSGPPRAALGKSSYGVAAPVDFLR
KQSQLLRSRGPSQAEREGPGTPPTTLARGKARSISLKLDSEE*
iRFP-Nir1-LNS2 miRFP670-Nir1613-897 This Study MVAGHASGSPAFGTASHSNCEHEEIHLAGSIQPHGALLVVSEHDH
RVIQASANAAEFLNLGSVLGVPLAEIDGDLLIKILPHLDPTAEGMPVA
VRCRIGNPSTEYCGLMHRPPEGGLIIELERAGPSIDLSGTLAPALERI
RTAGSLRALCDDTVLLFQQCTGYDRVMVYRFDEQGHGLVFSECH
VPGLESYFGNRYPSSTVPQMARQLYVRQRVRVLVDVTYQPVPLEP
RLSPLTGRDLDMSGCFLRSMSPCHLQFLKDMGVRATLAVSLVVGG
KLWGLVVCHHYLPRFIRFELRAICKRLAERIATRITALESGGSGGMP
ANPREKWLRKRTQVKLRNVTANHRANDVIAAEDGPQVLVGRFMY
GPLDMVALTGEKVDILVMAEPSSGRWVHLDTEITNSSGRITYNVPR
PRRLGVGVYPVKMVVRGDQTCAMSYLTVLPRGMECVVFSIDGSFA
ASVSIMGSDPKVRPGAVDVVRHWQDLGYMILYITGRPDMQKQRVV
SWLSQHNFPQGMIFFSDGLVHDPLRQKAIFLRNLMQECFIKISAAY
GSTKDISVYSVLGLPASQIFIVGRPTKKYQTQCQFLSEGYAAHLAAL
EASHRSRPKKN*
iRFP-Tubby M. musculus Tubby243-505-miRFP670 (Quinn et al., 2008) MVDIEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHL
DREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS
NLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGF
KGPRKMSVIVPGMNMVHERVCIRPRNEHETLLARWQNKNTESIIEL
QNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQF
GRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACETVPRARDPPV
ATMVAGHASGSPAFGTASHSNCEHEEIHLAGSIQPHGALLVVSEH
DHRVIQASANAAEFLNLGSVLGVPLAEIDGDLLIKILPHLDPTAEGMP
VAVRCRIGNPSTEYCGLMHRPPEGGLIIELERAGPSIDLSGTLAPAL
ERIRTAGSLRALCDDTVLLFQQCTGYDRVMVYRFDEQGHGLVFSE
CHVPGLESYFGNRYPSSTVPQMARQLYVRQRVRVLVDVTYQPVP
LEPRLSPLTGRDLDMSGCFLRSMSPCHLQFLKDMGVRATLAVSLV
VGGKLWGLVVCHHYLPRFIRFELRAICKRLAERIATRITALES*
iRFP-PH-PLCδ1 iRFP713-R. norvegicus PLCD12-131
(Idevall-Hagren et al., 2012)
MAEGSVARQPDLLTCDDEPIHIPGAIQPHGLLLALAADMTIVAGSDN
LPELTGLAIGALIGRSAADVFDSETHNRLTIALAEPGAAVGAPITVGF
TMRKDAGFIGSWHRHDQLIFLELEPPQRDVAEPQAFFRRTNSAIRR
LQAAETLESACAAAAQEVRKITGFDRVMIYRFASDFSGEVIAEDRC
AEVESKLGLHYPASTVPAQARRLYTINPVRIIPDINYRPVPVTPDLNP
VTGRPIDLSFAILRSVSPVHLEFMRNIGMHGTMSISILRGERLWGLIV
CHHRTPYYVDLDGRQACELVAQVLAWQIGVMEECTRDLELKLHGL
QDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKV
MRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQ
RNTLDLIAPSPADAQHWVQGLRKIIHHSGSMDQRQK*
TagBFP2-CAAX TagBFP2-HRAS172-189 (Goulden et al., 2019) MVSELIKENMHMKLYMEGTVDNHHFKCTSEGEGKPYEGTQTMRIK
VVEGGPLPFAFDILATSFLYGSKTFINHTQGIPDFFKQSFPEGFTWE
RVTTYEDGGVLTATQDTSLQDGCLIYNVKIRGVNFTSNGPVMQKKT
LGWEAFTETLYPADGGLEGRNDMALKLVGGSHLIANAKTTYRSKK
PAKNLKMPGVYYVDYRLERIKEANNETYVEQHEVAVARYCDLPSK
LGHKLNSGLRSRAQASNSAVDNPPDESGPGCMSCKCVLS*