Figure 2. Pathways and genes with differentially methylated regions in RSTR and LTBI monocytes.

Differentially methylated regions (DMR) were analyzed with hypergeometric mean pathway enrichment analysis with Broad MSigDB gene sets. (A) Gene ontology gene sets significantly enriched in DMR (FDR < 0.2 and k/K > 0.04). Gene sets visualized by semantic similarity in MDS space. Each dot is a gene set with size indicating percent enrichment (k/K * 100) and colors grouping similar terms. (B) DMR genes within significant GO gene sets. Colored boxes indicate presence in gene sets as in (A). Fold changes of probes in differentially methylated regions (DMR) are indicated by + positive for all probes, − negative for all probes, and −/+ variable across probes with the mean region trend in parentheses.