Table 1. Summary data, associated publications, and data sources for the four Behavioral Disinhibition traits, four Substance Use Disorder traits, and seven pre-registered Substance Use traits initially considered for the Substance Use Factor.
N = raw sample size used. Note that, in some cases, sample sizes in publicly available data are lower than total sample size reported in the corresponding publication(s) or in the table because of data access restrictions on some cohorts. Neff = effective sample size (for dichotomous traits), as provided in the summary statistics or calculated with respect to prevalence and sample size across cohorts. h2SNP = the proportion of trait variation in the sample(s) accounted for by variation in single nucleotide polymorphisms (SNPs). See sections 2.2.1–2.2.3 for further descriptions of phenotypes. ADHD = Attention-deficit Hyperactivity Disorder, NSEX = Number of Lifetime Sexual Partners, FSEX = Age at First Sexual Intercourse (reverse-coded), RISK = General Risk Tolerance, PTU = Problem Tobacco Use, PAU = Problem Alcohol Use, CUD = Cannabis Use Disorder, OUD = Opioid Use Disorder, CI = Cannabis Initiation, SI = Smoking Initiation, DPW = Drinks per Week, DRUG = Drug Experimentation (the number of different classes of drugs an individual has used out of eleven), CPD = Cigarettes per Day, DRINK STAT = Drinking Status (drinker vs. non-drinker), FREQ = Drinking Frequency.