Table 4 |. CSF and plasma-based inflammatory biomarker analysis.
A value of “NA” is included for targets in which three or more participants had undetectable values or %CV values exceeding 15. POST-PRE values are in pg/ml. CSF, N=9; Plasma, N=12. Normality testing was based on the POST-PRE difference for each target; P values are based on two-sided paired sample t-test (normal distribution) or Wilcoxon matched-pairs signed rank test (non-normal distribution). IQR=Interquartile Range.
| CSF |
PLASMA |
|||||
|---|---|---|---|---|---|---|
| PROTEIN | POST-PRE (IQR) | P VALUE | PROTEIN | POST-PRE (IQR) | P VALUE | |
| bFGF | NA | NA | bFGF | 0.6377 (−1.97, 1.02) | >0.9999 | |
| CRP | 39.06 (−7246, 1342) | >0.9999 | CRP | −903927 (−2106270, 118451) | 0.063 | |
| Eotaxin | NA | NA | Eotaxin | 210.8 (39.0, 439) | 0.092 | |
| Eotaxin-3 | NA | NA | Eotaxin-3 | 3.271 (−1.88, 7.34) | 0.398 | |
| Flt1 | −6.977 (−14.0, 1.15) | *0.050 | Flt-1 | −1.081 (−7.16, 1.57) | 0.380 | |
| IFN-g | NA | NA | IFN-g | 0.9857 (−0.233, 1.46) | 0.206 | |
| IL-1a | NA | NA | IL-1a | NA | NA | |
| IL-1b | NA | NA | IL-1b | NA | NA | |
| IL-2 | NA | NA | IL-2 | NA | NA | |
| IL-4 | NA | NA | IL-4 | NA | ND | |
| IL-5 | −0.03144 (−0.119, 0.454) | 0.298 | IL-5 | −0.01947 (−0.169, 0.0651) | 0.718 | |
| IL-6 | −0.06009 (−0.0209, 0.0595) | 0.364 | IL-6 | −0.04436 (−0.866, 0.275) | 0.622 | |
| IL-7 | −0.01858 (−0.0544, 0.0745) | 0.576 | IL-7 | 0.1686 (−1.61, 0.441) | 0.311 | |
| IL-8 | −1.844 (−5.63, 2.45) | 0.377 | IL-8 | 0.5924 (−1.21, 17.9) | 0.677 | |
| IL-10 | NA | NA | IL-10 | 0.04822 (−0.0142, 0.0854) | 0.064 | |
| IL-12_ | IL-12_ | |||||
| IL-23p40 | 0.1495 (−0.576, 0.459) | >0.9999 | IL23p40 | −0.5283 (−34.3, 31.2) | 0.967 | |
| IL-13 | NA | NA | IL-13 | NA | NA | |
| I-15 | 0.09699 (−0.284, 0.345) | 0.652 | IL-15 | 0.2861 (0.150, 0.456) | ***0.006 | |
| IL-16 | 0.1714 (−0.284, 0.449) | 0.719 | IL-16 | 0.9511 (−10.1, 10.6) | 0.860 | |
| IL-17a | −0.002132 (−0.0867, 0.0664) | 0.956 | IL-17A | −0.04166 (−0.141, 0.0588) | 0.417 | |
| IP-10 | 12.55 (−82.4, 40.3) | 0.910 | IP-10 | 30.29 (−46.4, 61.2) | 0.470 | |
| MCP-1 | 21.2 (5.33, 34.7) | 0.076 | MCP1 | 15.5 (−18.1, 52.1) | 0.208 | |
| MCP-4 | −0.006317 (−0.0945, 0.140) | 0.884 | MCP4 | 47.17 (−31.7, 82.5) | 0.155 | |
| MDC | NA | NA | MDC | −14.69 (−44.7, 86.7) | >0.9999 | |
| MIP-1a | NA | NA | MIP-1a | 1.421 (−0.391, 3.30) | 0.279 | |
| MIP-1b | −0.6947 (−2.51, 1.42) | 0.383 | MIP-1b | −0.2869 (−18.2, 8.90) | 0.6772 | |
| PIGF | −0.7235 (−1.71, 0.180) | 0.118 | PIGF | −0.05237 (−0.919, 0.942) | 0.883 | |
| SAA | −72.3 (−394, 4.49) | 0.055 | SAA | −109699 (−1116509, 173190) | 0.340 | |
| siCAM | 219.8 (−112, 480) | 0.165 | siCAM | −10037 (−67421, 46858) | 0.605 | |
| svCAM | −57.57 (−647, 638) | 0.857 | svCAM | 8605 (−46964, 50495) | 0.721 | |
| TARC | −0.157 (−0.509, 0.121) | 0.257 | TARC | 3.749 (−12.8, 10.4) | 0.850 | |
| Tie−2 | NA | NA | Tie-2 | −123.3 (−623, 257) | 0.331 | |
| TNF-a | NA | NA | TNF-a | 0.006858 (−0.102, 0.201) | 0.791 | |
| TNF-b | NA | NA | TNF-b | NA | NA | |
| VEGF-A | 0.08938 (−0.0830, 0.355) | 0.203 | VEGF-A | 0.1319 (−1.01, 1.36) | 0.850 | |
| VEGF-C | −8.791 (−28.8, 7.79) | 0.192 | VEGF-C | 2.184 (−70.6, 49.5) | 0.791 | |
| VEGF-D | −3.987 (−9.22, 3.48) | 0.199 | VEGF-D | 81.78 (−88.2, 245) | 0.250 | |