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[Preprint]. 2024 Feb 29:rs.3.rs-3964789. [Version 1] doi: 10.21203/rs.3.rs-3964789/v1

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Morris Water Maze to evaluate the effect of age, ovariectomy, and genetic Fshr depletion in 3xTg females on retrieval of spatial memory. In 5–month–old sham–operated 3xTg mice (A), time spent in the 40–cm platform zone in the absence of the platform showed a trend to significance for 3xTg;Fshr^−/− mice compared with 3xTg;Fshr^+/+ mice. At 10 months (B), the effect was significant for 3xTg;Fshr^+/− compared with 3xTg;Fshr^+/+ mice and showed a trend toward significance in 3xTg;Fshr^−/− mice compared with 3xTg;Fshr^+/+ mice. In ovariectomized mice, there was no difference between the groups at 5 months of age (C), but at 10 months (D), the 3xTg;Fshr^−/− mice showed longer time spent in the platform zone compared with the 3xTg;Fshr^+/− group. Mice that showed repeated episodes of extensive floating (>25% of trial time) were excluded from the analysis. N=10 to 14 mice per group; Mean ± SEM; P values as shown, significant at P≤0.05; repeated measures ANOVA followed by Fisher’s Least Significant Difference post–hoc analyses).