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[Preprint]. 2024 Feb 29:rs.3.rs-3964789. [Version 1] doi: 10.21203/rs.3.rs-3964789/v1

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The effect of Fshr depletion in 10–month–old 3xTg females following sham operation (Sham) or ovariectomy (OVX) on the accumulation of amyloid b (b) isoforms, Ab40 (A) and Ab42 (B) in whole brain extracts. There was a gene–dose–dependent reduction of Ab40 accumulation in both sham–operated and ovariectomized groups, but reductions in Ab42 were significant only in the sham–operated 3xTg;Fshr^−/−group. Sham: N=6–8/group, OVX: N=7–9/group; Mean ± SEM; P values as shown, significant at P≤0.05, Student’s t-test.