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[Preprint]. 2024 Feb 29:rs.3.rs-3964789. [Version 1] doi: 10.21203/rs.3.rs-3964789/v1

Figure 6.

Figure 6

Morris Water Maze to evaluate the effect of elevated FSHin 15–month–old APPIPS1 females on acquisition and retrieval of spatial memory. (A) In 16–month–old APP/PS1female mice, latency to find the hidden platform (seconds, s) was not different among the groups. Mice that showed repeated episodes of extensive floating (>10 s per trial or >25% of trial time across 5 days) were excluded from the analysis. (B) The effect of elevated FSH in the same mouse groups at day 7 in the retention trial which the platform was removed and time spent around the 40–cm platform center point (platform zone) was determined. Mice with low FSH levels showed significantly greater time spent in the platform zone. Mice that showed repeated episodes of extensive floating (>25% of trial time) were excluded from the analysis. N=13 to 15 mice per group; Mean ± SEM; P values as shown, significant at P≤0.05; repeated measures ANOVA followed by Fisher’s Least Significant Difference post–hoc analyses).