Table 2.
Association between plasma NfL and hippocampus subfields volume.
| Correlation P value (r) | ||
|---|---|---|
| CN− | MCI | |
| CA1 | .063 (−0.199) | .001 (−0.267) |
| CA2_3 | .032 (−0.228) | .007 (−0.224) |
| CA4_DG | .028 (−0.235) | .004 (−0.241) |
| Fimbria | .416 (0.088) | .006 (−0.231) |
| Hippocampal Fissure | .021 (−0.246) | .145 (−0.123) |
| Presubiculum | .327 (−0.106) | <.001 (−0.327) |
| Subiculum | .066 (−0.197) | <.001 (−0.282) |
| Tail | .397 (−0.091) | .052 (−0.164) |
Partial correlation results showed that plasma NfL was closely related to cortical volume in bilateral CA1, CA2_3, CA4_DG, fimbria, presubiculum, and subiculum in patients with MCI. The correlation between NfL and pre-subiculum and subiculum was particularly pronounced and significant. In CN− group, plasma NfL was significantly correlated with CA2_3, CA4_DG, and hippocampal fissure in the CN− group. No correlation between plasma NfL and hippocampal subregion volume was found in the CN + and AD groups. The composite-ROI includes the bilateral angular gyrus, posterior cingulate/precuneus, and inferior temporal cortex
Abbreviations: CA, cornuammonis; DG, dentate gyrus. CN− Amyloid-beta negative cognitively normal, CN + Amyloid-beta positive cognitively normal, MCI mild cognitive impairment, AD Alzheimer’s disease.