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[Preprint]. 2024 Feb 26:rs.3.rs-3976896. [Version 1] doi: 10.21203/rs.3.rs-3976896/v1

Figure 1. Loss of NE neurons in the LC in 5xFAD mice at advanced amyloid pathology stage.

Figure 1

a Representative 20x confocal images of LC neurons immunolabeled with TH (scale bar = 100mm). b Representative soma detection using Cellpose custom-trained model. c-h Number and size of LC neurons are comparable between control and 5xFAD mice at 4 months (c-d) and 6 months (e-f), LC neuron number is lower while neuronal size is larger at 9 months in 5xFAD compared to control mice (g-h). n = 7–9 mice per genotype per age group. Student t-test; *p<0.05, **p<0.01.