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[Preprint]. 2024 Feb 26:rs.3.rs-3976896. [Version 1] doi: 10.21203/rs.3.rs-3976896/v1

Figure 7. Prolonged exposure to β2AR agonist attenuates amyloid pathology and associated neuritic damage in the ACC in male 5xFAD mice.

Figure 7

a Representative 20x confocal images of the ACC immunolabeled for plaque (6E10, blue), plaque-associated neuritic damage (LAMP1, green), and microglia (Iba1, magenta) in male 5xFAD mice treated with saline control (upper panels) or β2AR agonist clenbuterol (lower panels) (scale bar = 200μm). All animals were 3 months old at the start of treatments. b-g Quantification of plaque load, neuritic damage, and microglia activation in the ACC of male 5xFAD mice after 1 month (b-d, n = 8 mice per treatment) or 2 months (e-g, n = 5 mice per treatment) of daily i.p. injections with saline or clenbuterol (CN). Student t-test; *p<0.05, **p<0.01, ***p<0.001.