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. 2024 Mar 10;14:5843. doi: 10.1038/s41598-024-56337-2

Table 5.

Mean number of encysted T. spiralis larvae/one gram of mouse muscle when euthanized post each different regime of treatment (mean body weight = 32 g and n = 5).

Treated & control
Group of mice
Dose of treatment Mean ± SD Treatment efficacy The infectivity of the cyst
Group (I) Infected Treated with Ag-NPs at 3rd, 4th and 5th dpi 21.5 mg/kg 45 ± 6.7* 86.61% No
21.5 mg/kg + MM 5 mg/kg 36.8 ± 5.45* 89.07% No
Albendazole 50 mg/kg 37.6 ± 4.97* 88.84% No
Infected untreated mice 336.8 ± 13.84 - No
Group (II) Infected Treated with Ag-NPs at 8th, 9th and 10th dpi 21.5 mg/kg 119.6 ± 7.16* 70.77% Dead
21.5 mg/kg + MM 5 mg/kg 105.2 ± 6.43* 74.29% Dead
Albendazole 50 mg/kg 111.4 ± 5.94* 72.78% Dead
Infected untreated mice 409.2 ± 25.59 - Infective
Group (III) Infected Treated with Ag-NPs at 33rd, 34th and 35th dpi 21.5 mg/kg 255.2 ± 28.33* 55.73% Not infective
21.5 mg/kg + MM 5 mg/kg 243.6 ± 16.52* 57.81% Not infective
Albendazole 50 mg/kg 268.8 ± 30.87* 53.47% Infective
Infected untreated mice 576.4 ± 42.16 - Infective
Group (IV) Control non-infected mice 0 0 No

*P-value < 0.001 statistically significant.