Table 2.
Lymphoid composition of the lymphocytic foci of the MSGB and comparison of main outcomes.
| Variable | Progression (n=16) |
Stable disease (n=62) |
p | ESSDAI improvement (n=8) | No ESSDAI improvement (n=70) |
p | Total (n=78) |
|---|---|---|---|---|---|---|---|
| Number of lymphocytic foci, (n, %) 0 1 2 ≥3 |
1.5 1 (6.25) 7 (43.75) 2 (12.5) 6 (37.5) |
1 6 (9.68) 33 (53.23) 13 (20.97) 10 (16.13) |
0.10 | 1 1 (12.5) 4 (50) 1 (12.5) 2 (25) |
1 6 (8.57) 36 (51.43) 14 (20) 14 (20) |
0.94 | 1.53 (0.95) 7 (8.97) 40 (51.28) 15 (19.23) 16 (20.51) |
| Total number of lymphocytes, mean (SD) | 191.56 (256.17) | 121.04 (112.52) | 0.12 | 100.63 (101.26) | 139.5 (158.68) | 0.58 | 85 (120) |
| Number of T cells, mean (SD) | 115 (157.05) | 58.95 (38.77) | 0.03 | 45.63 (40.57) | 73.29 (83.80) | 0.29 | 55 (55) |
| Number of T CD4 cells, mean (SD) | 82.11 (103.20) | 41.4 (25.14) | 0.03 | 32.92 (25.16) | 51.26 (54.78) | 0.33 | 35 (36.67) |
| Number of T CD8 cells, mean (SD) | 49.32 (67.12) | 24.69 (17.67) | 0.04 | 27.92 (21.79) | 29.86 (35.88) | 0.85 | 18.33 (16.25) |
| Number of B cells, mean (SD) | 76.56 (132.71) | 62.10 (84.06) | 0.57 | 55 (76.25) | 66.21 (72.25) | 0.86 | 30 (90) |
| % T cells/Total lymphocytes, mean (SD) | 69.48 (29.91) | 63.40 (27.98) | 0.46 | 0.53 (0.37) | 0.66 (0.27) | 0.26 | 0.65 (0.28) |
| % B cells/Total lymphocytes, mean (SD) | 30.52 (29.91) | 36.60 (27.98) | 0.46 | 0.47 (0.37) | 0.34 (0.27) | 0.26 | 0.35 (0.28) |
| % T CD4 cells/Total T cells, mean (SD) | 64.29 (11.98) | 62.64 (15.29) | 0.73 | 0.56 (0.18) | 0.64 (0.14) | 0.19 | 0.63 (0.15) |
| % T CD8 cells/Total T cells, mean (SD) | 35.71 (12.0) | 37.36 (15.29) | 0.77 | 0.44 (0.18) | 0.36 (0.14) | 0.25 | 0.37 (0.15) |
| Presence of isolated infiltrate without lymphocytic foci, (n, %)+ | 3 (18.75) | 11 (17.74) | — | 1 (12.5) | 13 (18.57) | — | 14 (17.95) |
Comparison was not carried out in a small number of cases (<5).