| 1B | For the treatment of primary, secondary, or early latent syphilis, a single intramuscular injection of benzathine penicillin G 2.4 million units is recommended. |
| 1C | For the treatment of late latent syphilis or latent syphilis of unknown duration, a regimen of 3 intramuscular injections of benzathine penicillin G 2.4 million units at weekly intervals is recommended. |
| 1C | As an alternative therapy for patients with primary, secondary, or early latent syphilis and penicillin allergies, an oral administration of doxycycline 100 mg twice daily for 14 days is recommended. |
| 2D | For patients with late latent syphilis or latent syphilis of unknown duration and penicillin allergies, an oral administration of doxycycline 100 mg twice daily for 28 days is recommended. |
| 1B | In pregnant females with primary, secondary, or early latent syphilis, a single intramuscular injection of benzathine penicillin G 2.4 million units is recommended. Desensitization, followed by penicillin treatment, is recommended for patients with penicillin allergies. |
| 1C | For pregnant females with late latent syphilis or latent syphilis of unknown duration, 3 intramuscular injections of benzathine penicillin G 2.4 million units at weekly intervals are recommended. Desensitization, followed by penicillin treatment, is recommended for patients with penicillin allergies. |