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. 2024 Mar 4;65(2):115–123. doi: 10.4111/icu.20230322
1B For the treatment of primary, secondary, or early latent syphilis, a single intramuscular injection of benzathine penicillin G 2.4 million units is recommended.
1C For the treatment of late latent syphilis or latent syphilis of unknown duration, a regimen of 3 intramuscular injections of benzathine penicillin G 2.4 million units at weekly intervals is recommended.
1C As an alternative therapy for patients with primary, secondary, or early latent syphilis and penicillin allergies, an oral administration of doxycycline 100 mg twice daily for 14 days is recommended.
2D For patients with late latent syphilis or latent syphilis of unknown duration and penicillin allergies, an oral administration of doxycycline 100 mg twice daily for 28 days is recommended.
1B In pregnant females with primary, secondary, or early latent syphilis, a single intramuscular injection of benzathine penicillin G 2.4 million units is recommended. Desensitization, followed by penicillin treatment, is recommended for patients with penicillin allergies.
1C For pregnant females with late latent syphilis or latent syphilis of unknown duration, 3 intramuscular injections of benzathine penicillin G 2.4 million units at weekly intervals are recommended. Desensitization, followed by penicillin treatment, is recommended for patients with penicillin allergies.