TABLE 1.
Role of different miRNAs with impact on vascular senescence.
| miRNAs | Target genes | Role in vascular senescence | References |
|---|---|---|---|
| miR-504 | p53 | Lowers p53 activity and abundance and promotes VSMC dysfunction | Reddy et al. (2016) |
| miR-122 | CPEB | Reduces translation and polyadenylation of p53 mRNA in fibroblasts | Burns et al. (2011) |
| miR-605 | MDM2 | Activates p53-mediated senescence and downregulates p21WAF1/Cip1 in HMECs and regulates secretion of CXCL5 in ECs | Borgdorff et al. (2010), Pande et al. (2021) |
| miR-17–3p | Par4 | Negative modulator of cardiac aging and cardiac fibroblast cellular senescence | Du et al. (2015) |
| miR-126–5p | Dlk1 | Promotion of the proliferation of ECs | Schober et al. (2014) |
| miR-21 | PTEN | Abnormal proliferation of VSCMs | Hutcheson et al. (2014) |
| miR-206 | VEGF | Regulation of CAD progression | Wang et al. (2016a) |
| miR-23a | EGFR | Inhibition of cell migration and vasculogenesis of CAD | Wang et al. (2016b) |
| miR-361–5p | VEGF | Antiangiogenic effect in acute coronary syndrome | Wang et al. (2014) |
| miR-574–5p | ZDHHC14 | Proliferation of VSMCs and inhibition of apoptosis in CAD | Lai et al. (2018) |
| miR-33 | ABCA1/ABCG1 | Inhibition of cholesterol efflux in aged macrophages | Ono (2016) |