FIGURE 3.

Gene-wide linkage plots reveal SNPs in linkage with rs3199966 are also associated with cognitive measures. LD plots were generated for the 6 cognitive measures from Table 4: (A) General Cognitive Abilities, (B) Nonverbal Reasoning, (C) Recall of Designs, (D) Sequential Quantitative Reasoning, (E) Conners Executive Functioning, and (F) CVLT Serial Cluster Ratio. The x-axis is the position on the chromosome in kilobase pairs. The y-axis is −log₁₀(P value). Each SNP is represented by a triangle, with the purple diamond representing rs3199966. The warmth of the color indicates the strength of LD of a SNP with rs3199966 as per the scale bar at the bottom right. Because linkage strength varies with genetic ancestry, LD was calculated based on all participants (ALL), and separately for participants having European (EUR) and African (AFR) ancestries. The blue line indicates recombination hot spots. LD, linkage disequilibrium; SNP, single nucleotide polymorphism.