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. 2023 Aug 12;43(12):2060–2071. doi: 10.1177/0271678X231195243

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© The Author(s) 2023

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Thirteen of the 18 biomarkers that each significantly correlated with CBF formed one cluster according to both prior knowledge and data-driven cluster analyses. Biomarkers that were found to be involved based on prior knowledge (with information from the STRING database) are shown in green. Four additional biomarkers that were found to extend this cluster based on data-driven cluster analyses are shown in blue. Line width reflects the strength of data support. Data-driven extensions are shown as dashed lines.