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. 2024 Mar 4;35:564–576. doi: 10.1016/j.bioactmat.2023.11.019

Fig. 2.

Fig. 2

Repolarization of macrophages from M1 toward M2 phenotype by apoEVs. (a) Representative images showing the cellular uptake of DiD-labeled apoEVs (red) by macrophages. (Scale bar, 20 μm) (b) FCM analysis of CD206 and CCR7 expression. (c) Representative images of iNOS (red) in macrophages. (Scale bar, 25 μm) (d) Representative images of ROS (green) production by macrophages. (Scale bar, 100 μm) (e) Concentration of NO in the culture medium by Griess assay. (n = 5) (f) Concentration of TNF-α, TGF-β1, and Arg1 in the culture medium by ELISA. (n = 3) (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).