Table 1:
Summary statistics of the JoCoOA and FNIH cohorts.
| Baseline Characteristics | JoCoOA Controls | FNIH OA Cases |
|---|---|---|
| Total n | 127 | 596 |
| Female n (%) | 80 (63%) | 350 (59%) |
| Age median (years) [Min, Max] | 59.0 [45.0, 95.0] | 61.0 [45.0, 79.0] |
| BMI median (kg/m2) [Min, Max] | 28.2 [20.0, 54.4] | 30.2 [18.6,46.7] |
| Race | ||
| 0 (0%) | 11 (2%) | |
| 85 (67%) | 474 (79%) | |
| 42 (33%) | 108 (18%) | |
| Asian | 0 (0%) | 5 (1%) |
| Knee KL grade | ||
| 127 (100%) | 0 (0%) | |
| 0 (0%) | 75 (12.6%) | |
| 0 (0%) | 303 (50.8%) | |
| 3 | 0 (0%) | 218 (36.6%) |
| WOMAC pain mean (SD) | 1 (2.5)* | 12.0 (15.5)* |
KL: Kellgren Lawrence grade knee OA
WOMAC: Western Ontario and McMaster Universities Arthritis Index pain score normalized on a 0–100 scale
The majority (76%) of JoCoOA controls had baseline WOMAC pain scores of 0; a total of 231 (39%) of FNIH cases had baseline WOMAC pain scores of 0.
The random parsing led to well-balanced of training and testing sets that were not significantly different from the overall combined cohort shown in the Table (data not shown).