Skip to main content
. Author manuscript; available in PMC: 2024 Mar 11.
Published in final edited form as: Cell Rep. 2024 Jan 5;43(1):113636. doi: 10.1016/j.celrep.2023.113636

Figure 4. Neurofilament protein and retromer complex component abundances track inversely with increasing TDP-43 aggregation in postmortem human MNs.

Figure 4.

(A) Volcano plot of Spearman rank correlations (Rs) for abundance of individual proteins vs. corresponding TDP-43 stratum; purple highlight, significantly (p-adj < 0.05, Bonferroni) correlated proteins; green dashed lines indicate NfP correlations.

(B) Distribution of NEFH, NEFM, and NEFL protein abundances in individual MNs across TDP-43+ NCI strata.

(C) (i) Over-represented (blue highlight; p-adj < 0.05, p-adj < 0.01, Benjamini-Hochberg) KEGG pathways and (ii) physical protein complex assignments for the top 5% negative TDP-43-correlators; median ± IQR; whiskers indicate range.

(D) TDP-43-stratified protein abundances trajectories for retromer (blue), GARP/EARP (mauve), HOPS/CORVET (teal), and ESCRT-III (gold); median ± IQR; whiskers indicate range.

(E) Glial:neuronal abundance ratios for proteins with significant, positive RS.

(F) TDP-43-stratified protein abundance trajectories for SYNM and CNTNAP2; median ± IQR; whiskers indicate range.