Table 3.

Most relevant DEG discrepancies between Oncopig and human cells in response to gemcitabine treatment.

Cellular Process	GENE	Function	Human	Oncopig
Apoptosis	Caspase 3	Execution of apoptosis	Up	No difference
Apoptosis	Caspase 10	Execution of apoptosis	Up	No difference
Apoptosis	CASP8AP2	Regulatory role in Fas-mediated apoptosis	Up	No difference
Apoptosis	TP73	Member of the P53 family of transcription factor. Apoptosis response to DNA damage	Up	No difference
Apoptosis	TP53	Tumor suppressor gene. Apoptosis response to DNA damage	Down	No difference
Apoptosis	FAS	Member of the TNF-receptor superfamily. Physiological regulation of programmed cell death	Up	No difference
Apoptosis	Rb1	Tumor suppressor gene. Negative regulator of the cell cycle	Up	No difference
Apoptosis	MDM4	Inhibits Tp53 and Tp73-mediated cell cycle arrest and apoptosis	No difference	Up

Differences in expression are expressed as changes in treated compared to control groups (cells exposed only to medium).