Table 5.
Human, pig, and mouse activation energies.
| Protein | ΔG (kcal/mol) Human |
ΔG (kcal/mol) Swine |
ΔG (kcal/mol) Murine | Chemotherapy drug |
|---|---|---|---|---|
| CYP450 | -6.68 | -6.44 | -6.59 | gemcitabine |
| CYP450 | -12.26 | -11.87 | -12.44 | doxorubicin |
| CYP450 | -5.99 | -4.91 | -7.3 | cisplatin |
| DCK | -6.98 | -6.88 | -6.47 | gemcitabine |
| ENT1 | -6.29 | -5.86 | -6.29 | gemcitabine |
| CMPK1 | -5.27 | -5.28 | -5.68 | gemcitabine |
| AKR1A1 | -11.75 | -10.35 | -10.19 | doxorubicin |
| NQO1 | -9.52 | -9.09 | -9.98 | doxorubicin |
| PI3K | -7.71 | -6.01 | -6.72 | cisplatin |
Values referring to the activation energy in kcal/mol (Δg) of each protein and its respective ligand (chemotherapeutic agent).