Table 1.
Autoantibodies reported in healthy Centenarians.
| N | Autoantibody | Comment | Year, (reference) |
|---|---|---|---|
| 34 | Tg (2.9%), TPO (5.8%), PCA (0), AC (0) | The prevalence of serum anti-Tg and anti-TPO antibodies was low in centenarians as compared with older adults and did not differ from that in younger healthy controls. | 1992 [19] |
| 26 | PCA (0), Tg (4%), ACA IgG (58%), ACA IgM (23%), ANA (27%), ds- DNA (0), ENA (0), h-GAL (58%) | 2002 [20] | |
| 140 | Tg (10.7%), TPO (9.3%) | Of an initial cohort of 209 centenarians, 6 (2.87%) disclosed hypothyroidism, and another 6 hyperthyroidism. The 140 centenarians evaluated were free of thyroid disease. | 1999 [14] |
| 20 | RF (25%), ANA (15%) | ANA were positive in three centenarians at titers >1:160, by IFI. Authors hypothesized that a raised sCD30 levels in centenarians, could be responsible, at least in part, for the appearance of circulating autoantibodies without definite clinical consequences at advanced age | 2001 [21] |
| 26 | PCA (0), Tg (4%), ACA IgG (58%), ACA IgM (23%), ANA (27%), ds- DNA (0), ENA (0), h-GAL (58%) | 1997 [22] | |
| 24 | Tg (4.16%), TPO (4.16%) | The occurrence of anti-Tg and anti-TPO positivity was lower in centenarians than in old and in young controls | 2002 [23] |
| 52–140 | Tg (11.4%), TPO (10%), PCA (18.6%), ANA (14.3%), IgM RF (26.6%), IgA RF (18.7%), MPO-ANCA (10.8%), ANCA (18%), PR3-ANCA (7.2%), oxLDL (15%), IgM ACA (14.3%), IgG ACA (2.1%), PR3-ANCA (7.2%), Histone (3.8%), Ro (1.9%) | Anti-La, anti-Sm, anti-U1RNP, and IgG/IgM antibodies to β2GP1 were not detected. | 2004 [24] |
| 77 | IgG β2GP1 (54.3%), IgM β2GP1 (8.6%), IgG ACA (20.7%), IgM ACA (2.59%) | Lupus anticoagulant was not detected. No vascular events were reported. | 2004 [18] |
| 33 | PARP | Class I 8 (24,24%), Class II 13 (39.4%), Class III 12 (36.36%). Classes depended on the magnitude of optical density results. | 2009 [25] |
Abbreviations: AC: adrenal cells; ACA: anti-cardiolipin antibodies; ANA: anti-nuclear antibodies; ANCA: antineutrophil cytoplasmic antibodies; β2GP1: beta 2 glycoprotein 1; h-GAL: natural anti-h-galactosyl antibodies; ds-DNA: anti-double strand DNA; ENA: anti-extractable nuclear antigens; IFI: indirect immunofluorescence; MPO: myeloperoxidase; oxLDL: oxidized low-density lipoprotein; PARP: poly(ADP-ribose) polymerase; PCA: parietal cell antibodies; RF: rheumatoid factor; Tg: thyroglobulin; TPO: thyroid peroxidase.