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. Author manuscript; available in PMC: 2025 Jan 24.
Published in final edited form as: J Am Chem Soc. 2024 Jan 8;146(3):1748–1752. doi: 10.1021/jacs.3c11219

Figure 3.

Figure 3.

Application of PaNDA to a 26-nt therapeutic DNA aptamer NU172. (A) Guanine imino region in the 1H-15N HSQC spectra recorded for the 13C,15N-labeled DNA aptamer NU172 at 12°C and 37°C in a buffer of 10 mM potassium phosphate (pH 7.4) and 100 mM NaCl, and 5% D2O. (B) Corresponding region of the spectra recorded for NU172 in a human serum. (C) Decay of the NU172 HSQC signals due to degradation in the serum.