TABLE 2.

Clinical significance of binary IL-6:sIL-6R complex, ternary IL-6:sIL-6R:sgp130 complex, and the ratio between binary and ternary complexes in NSCLC patients treated with ICI.

Patient characteristics	Median (SD)	HR (95%CI)	p-Value
Binary IL-6:sIL-6R complex	0.162 (0.031)	0.16 (0.00–688.48)	0.647
Ternary IL-6:sIL-6R:sgp130 complex	0.099 (0.016)	0.08 (0.00–556909.2)	0.727
Binary/Ternary complex ratio	1.644 (0.100)	0.21 (0.01–3.70)	0.273

Univariate analyses were performed using a Cox proportional hazards model for overall survival (OS).

Abbreviations: standard deviation (SD), hazard ratio (HR), confidence interval (CI), soluble IL-6R (sIL-6R), soluble gp130 (sgp130).