. 2024 Feb 20;15:1367092. doi: 10.3389/fmicb.2024.1367092

Table 6.

Diagnostic performance of LAM in combination of 1 other method in EPTB.

Methods	Results	CRS		Sensitivity	Increment	Specificity	PPV	NPV	Kappa
Methods	Results	EPTB	Non-TB	Sensitivity	Increment	Specificity	PPV	NPV	Kappa
LAM + smear	positive	18	0	42.86%^#	35.71%	100.00%	100%	60.66%	0.413
LAM + smear	negative	24	37	42.86%^#	35.71%	100.00%	100%	60.66%	0.413
LAM + culture	positive	22	0	52.38%^#	26.19%	100.00%	100%	64.91%	0.507
LAM + culture	negative	20	37	52.38%^#	26.19%	100.00%	100%	64.91%	0.507
LAM + RNA	positive	19	0	45.24%^#	35.71%	100.00%	100%	61.67%	0.436
LAM + RNA	negative	23	37	45.24%^#	35.71%	100.00%	100%	61.67%	0.436
LAM + Xpert	positive	26	0	61.90%*^#	28.57%	100.00%	100%	69.81%	0.604
LAM + Xpert	negative	16	37	61.90%*^#	28.57%	100.00%	100%	69.81%	0.604

CRS, composite reference standard; EPTB, extrapulmonary tuberculosis; PPV, positive predictive value; NPV, negative predictive value; RNA, ribonucleic acid; TB, tuberculosis; LAM, lipoarabinomannan; *p < 0.05, Compared to LAM; ^#p < 0.05, compared to single detection.