Table 1.
Bee antiviral protein-1 (bap1) orthologs are primarily under neutral selection.
| M0 | M1 | M2 | |
|---|---|---|---|
| Description | Assumes one dN/dS ratio for whole gene | Assumes near-neutral selection | Assumes 3 classes with varying selection (negative, neutral or positive) |
| -lnL | −160,366.55 | −154,730.907 | −154,513.0653 |
| Test Statistic (null is M0) | 11,271.286 | M2-M0: 11,706.97 | |
| M2-M1: 434 | |||
| p-value | <1 × 10−15 | M2-M0: <1 × 10−15 | |
| M2-M1: p < 0.001 | |||
| dN/dS | 0.628 | negative = 0.146, neutral = 1.000 | negative = 0.16 |
| neutral = 1.00 | |||
| positive = 1.94 |
Measures of selection (dN/dS) were calculated for bap1 (GenBank: MF116383) orthologs under three models. M0 assumes one dN/dS ratio for the whole protein. M1 assumes the protein is evolving under near-neutral selection and calculates dN/dS for two site classes (dN/dS = 1 and dN/dS <1). Lastly, M2 assumes there are three codon site classes in the protein (dN/dS < 1, dN/dS = 1 and dN/dS >1). The tests show M2 is the best model and that bap1 orthologs have sites under negative, neutral, and positive selection.