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. 2024 Mar 10;22:262. doi: 10.1186/s12967-024-05059-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — A The azaspiranic tetracyclic scaffold. B The workflow of this study. C The 119 overlapping targets between SP (353 targets) and STP (420 targets). D PPI networks (115 nodes, 603 edges). E A bubble chart of 37 signaling pathways against pan-cancer. F HSP90AA1—Nordeoxyharringtonine complex. G CASP8—Nordeoxyharringtonine complex. H TLR4—Nordeoxyharringtonine complex. I PRKCD—Nordeoxyharringtonine complex. J Density functional theory (DFT) plot and its energy gap (E_gap) for Nordeoxyharringtonine and conventional anticancer drugs. Red bar was indicated Nordeoxyharringtonine. K The key summary of this study

Fig. 1 — A The azaspiranic tetracyclic scaffold. B The workflow of this study. C The 119 overlapping targets between SP (353 targets) and STP (420 targets). D PPI networks (115 nodes, 603 edges). E A bubble chart of 37 signaling pathways against pan-cancer. F HSP90AA1—Nordeoxyharringtonine complex. G CASP8—Nordeoxyharringtonine complex. H TLR4—Nordeoxyharringtonine complex. I PRKCD—Nordeoxyharringtonine complex. J Density functional theory (DFT) plot and its energy gap (E_gap) for Nordeoxyharringtonine and conventional anticancer drugs. Red bar was indicated Nordeoxyharringtonine. K The key summary of this study