Table 2.

Crude and adjusted odds ratios of adverse perinatal outcomes according to COVID-19 vaccination

Adverse pregnancy outcome	Vaccination status	No.	No of cases. (%)	Unadjusted odds ratio (95%CI)	Unadjusted P value	adjusted odds ratio (95%CI)a	Adjusted p value
Preterm birth	unvaccinated	112,003	9,151(8.17)		Baseline
	vaccinated	17,485	1,396(7.98)	0.97(0.91 to 1.03)	0.40	0.91(0.85 to 0.97)	0.006
Extremely preterm birth	unvaccinated	112,003	1,497(1.34)		Baseline
	vaccinated	17,485	133(0.76)	0.56(0.47 to 0.67)	<0.001	0.55(0.45 to 0.66)	<0.001
Congenital anomaly	unvaccinated	112,003	382(0.34)		Baseline
	vaccinated	17,485	64(0.37)	1.07(0.82 to 1.39)	0.60	1.01(0.76 to 1.33)	0.94
Stillbirth	unvaccinated	112,003	815(0.73)		Baseline
	vaccinated	17,485	90(0.51)	0.70(0.56 to 0.87)	0.002	0.60(0.47 to 0.76)	<0.001
Intrauterine growth restriction	unvaccinated	112,003	2,169(1.94)		Baseline
	vaccinated	17,485	347(1.98)	.02(0.91 to 1.14)	0.66	1.04 (0.92 to 1.18)	0.44
Low birth weight	unvaccinated	112,003	7,007(6.2)		Baseline
	vaccinated	17,485	1,017(5.8)	0.92(0.86 to 0.99)	0.02	1.05(0.96 to 1.14)	0.27
Very low birth weight	unvaccinated	112,003	1,468(1.3)		Baseline
	vaccinated	17,485	145(0.8)	0.62(0.53 to 0.74)	<0.001	1.01(0.76 to 1.34)	0.90
NICU admission	unvaccinated	112,003	11,347(10.1)		Baseline
	vaccinated	17,485	1,762(10.0)	0.99(0.94 to 1.04)	0.82	1.00(0.94 to 1.06)	0.80
Low 5-minute Apgar score	unvaccinated	112,003	1,341(1.2)		Baseline
	vaccinated	17,485	153(0.8)	0.72(0.61 to 0.86)	<0.001	0.98(0.78 to 1.23)	0.88
Neonatal death	unvaccinated	112,003	146(0.13)		Baseline
	vaccinated	17,485	15(0.09)	0,65(0.38 to 1.11)	0.12	1.07(0.60 to 1.91)	0.80

^apreterm birth, extremely preterm birth, congenital anomalies, stillbirth, and IUGR are adjusted for maternal age, maternal underlying medical conditions, smoking or other addictions in pregnant mothers, maternal educational level, prepregnancy body mass individuals, and parity

LBW, VLBW, NICU admission, low 5-minute Apgar score, and neonatal death are adjusted for gestational age at birth, maternal age, maternal underlying medical conditions, smoking or other addictions in pregnant mother, maternal educational level, prepregnancy body mass individuals and parity.