Table 3.
Prevalence of the most common serotypes and strain lineages in the PCV pre- and post-uptake time periods
|
No. (%) of isolates of type† |
|||
|---|---|---|---|
|
Type* |
Pre-uptake |
Post-uptake |
P‡ |
|
Serotypes |
|||
|
1 |
46 (22) |
9 (5) |
3.23×10−6 |
|
5 |
13 (6) |
5 (3) |
0.153 |
|
6B |
6 (3) |
19 (10) |
0.024 |
|
9V |
5 (2) |
17 (9) |
0.024 |
|
14 |
10 (5) |
12 (6) |
0.753 |
|
19A |
6 (3) |
20 (10) |
0.024 |
|
19F |
12 (6) |
18 (9) |
0.329 |
|
23F |
8 (4) |
16 (8) |
0.153 |
|
GPSCs |
|||
|
1 |
2 (1) |
28 (15) |
2.29×10−6 |
|
2 |
46 (23) |
9 (5) |
2.29×10−6 |
|
6 |
3 (2) |
19 (10) |
1.23×10−3 |
|
8 |
13 (7) |
5 (3) |
0.125 |
|
9 |
10 (5) |
11 (6) |
0.932 |
|
10 |
10 (5) |
34 (18) |
2.33×10−4 |
|
23 |
2 (1) |
10 (5) |
0.048 |
|
Total |
205 |
197 |
|
*All types represented by >10 isolates in total are listed. Global pneumococcal sequence clusters (GPSCs) represent strain lineages.
†The pre- and post-uptake time periods were defined as in Fig. 1.
‡Test that the type proportion is equal in the pre- and post-uptake periods. P-values were adjusted for multiple testing within type by the Benjamini–Hochberg procedure.