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. 2023 May 18;3:1175568. doi: 10.3389/fopht.2023.1175568

Figure 1.

Figure 1

CUT&Tag sequencing reveals Pou4f1 occupancy in E16.5 RGCs. (A) Average density profiles (top) and heatmaps (bottom) showing Pou4f1 and IgG CUT&Tag signals in relation to transcription start site (TSS) ( ± 3 kb). (B) Motif enrichment analysis by HOMER of Pou4f1-bound elements displayed in (A). (C) Motif enrichment analysis by HOMER of Pou4f1-bound elements in panel (A) intersected with RGC-specific open chromatin regions. (D) Reactome pathway analysis of genes associated with RGC-specific Pou4f1-bound elements in panel (C). The top 10 most enriched reactome gene terms are presented using a dot-plot. (E) KEGG pathway analysis of genes associated with RGC-specific Pou4f1-bound elements in panel (C). The top 10 most enriched KEGG terms are displayed using a dot-plot. X-axis indicates the gene ratio in the term, and the Y-axis indicates the category term. The size of the dots represents the number of genes found in each category term. The color of the dots represents the adjusted P value.